Wei-Hsuan Hsu

• Ph.D.National Taiwan UniversityDepartment of Biochemical Science and Technology
• M.S.National Taiwan University　Institute of Microbiology and Biochemistry
• B.S.National Chiayi University　Department of Food Science

Current

• Associate Professor, Institute of Food Safety, Hygiene and Risk Management, National Cheng Kung University, 2023 ~
• Jointly appointed Associate Professor, Department of Public Health, National Cheng Kung University, 2025~
• Director – Taiwan Society for Extracellular Vesicles (TSEV) 2020~
• Guest Editor of Discover Food 2025~2026
• Guest Editor of Journal of Food and Drug Analysis 2024~
• Guest Editor of Foods 2024~
• Southern Taiwan Science Park Administration Project Review Committee 2024~
• Ministry of Agriculture Project Review Committee 2023~
• National Science and Technology Accounting Project Review Committee 2019~

Served

• Assistant Professor – National Cheng Kung University / Department of Food Safety/Hygiene and Risk Management 2018 ~ 2023
• Local Industrial Innovation R&D Promotion Program (Local SBIR) Review Committee Member 2023~2024
• Guest Editor of International Journal of Molecular Sciences 2022~
• Researcher –Industrial Technology Research Institute 2015~ 2018
• Postdoctoral researcher – Purdue University / Department of Medical Sciences 2014~ 2015
• Postdoctoral researcher – National Taiwan University / Department of Biochemical Science and Technology 2013~ 2014

• Taiwan Agricultural Chemical Society- Academic Achievement Award (2025)
• National Cheng Kung University- Outstanding Academia-Industry Cooperation Teacher Award (2025)
• Taiwan Health Food Society- Distinguished Academic Research Award (2025)
• Cheng-Hsing Medical Foundation- Excellent Paper Award (2024)
• The 21st National Innovation Award - Academic Research Innovation Award (2024)
• Taiwan University Young Scholars Innovative Research and Development Outstanding Award (2024)
• Future Technology Award (2024)
• International Society for Extracellular Vesicles Scholarship Fellow (2024)
• National Cheng Kung University Alumni Foundation Interdisciplinary Research Excellence Award (2024)
• Li Kuo-Ting Lectureship in Science, Technology and Humanities - Gold Award (2023)
• National Cheng Kung University College of Medicine 2021 Newcomer Best Paper Award (2023)
• National Cheng Kung University Higher Education Advanced Education Program Potential Scholars Equipment Grant (2022)
• National Cheng Kung University Academic Excellence Research Grant (2021)
• National Cheng Kung University New Faculty Equipment and Instrument Subsidy (2021)
• National Cheng Kung University New Teachers Ministry of Science and Technology Special Research Project Grant (2021)
• Top 10 Most Cited Researchers in Journal of Food and Drug Analysis 2019 (IF: 6.157) (2020)
• National Taiwan University of Economics Young Scholars Innovative Research Award (2019)
• National Cheng Kung University Faculty and Research Staff Flexible Salary and Research Incentive (2018-Present)
• Young Scholar Award of the Ministry of Science and Technology (2018)
• National Taiwan University Outstanding Performance Award (2012)
• Johnson & Johnson Outstanding Asian Biotechnology Graduate Paper Award (2011)

• A composition containing crystal ice flower extract can be used to improve memory impairment symptoms caused by Alzheimer's disease or diabetes. Country: Taiwan; Patent Number: I532489.
• Application of aqueous extracts or fermented products of plants from the family Gracilariaceae as pharmaceutical compositions and/or health foods for treating and/or alleviating neurological disorders. Country: Taiwan; Patent Number: I736781.
• Application for water extract of plant of Gracilariaceae or ferment thereof and pharmaceutical composition and/or health food for treating and/or alleviating nervous diseases.
  Country: United States; Patent Number: 11083762.
• The use of the water extract of the オコノリfamily plant, またはその発zyme, and the なびらた神経 Disease Sickness treatment and soothing medicine compositions and health food.
  Country: Japan; Patent Number: Patent No. 6816090 (P6816090).
• Lactic acid bacteria, compositions for improving intestinal microbial composition, and products and uses thereof. Country: Taiwan; Patent Number: I875299.
• Compositions for improving the composition of lactic acid bacteria and intestinal microorganisms, and lactic acid bacteria products and uses. Country: Japan; Patent number: Patent No. 7717865 (P7717865).

• Mentored Yang Ziying, Chen Yongzhen, and Lai Yirong to win third place in the junior high school category of the Elementary and Secondary School Science Fair (65th National Science Fair, July 2025)
• Graduate student Lin Huiqun won the Outstanding Graduate Paper Award (National Cheng Kung University School of Medicine Annual Research Day, May 2025)
• Graduate student Yang Shuhua won the Poster Meri Award (Multiomics and Precision Medicine Joint Conference, November 2024)
• Graduate student Feng Ruyi won the Outstanding Poster Paper Award (Taiwan Inspection and Quality Assurance Society (TTQAS) Academic Seminar and Members' Meeting, October 2024)
• Graduate student Liu Zongyu won the Outstanding Graduate Paper Award (National Cheng Kung University School of Medicine Annual Research Day, May 2024)
• Graduate student Qiaoyu Xu won the Excellent Student Paper Award (Taiwan Lactic Acid Bacteria Association Annual Conference and Symposium - The Great Future of Next-Generation Probiotics, December 2023)
• Graduate student Zhang Yicen won the Best Poster Award (Omics Lights Up Precision Medicine, November 2023)
• Graduate student Zhang Yicen won the Outstanding Graduate Paper Award (National Cheng Kung University School of Medicine Annual Research Day, May 2023)
• Special topic students Wu Yunzhen and Yang Ziyi won the Special Award at the Tainan District Science Fair (63rd Science Fair, April 2023)
• Research Assistant Chen Youzuo won the Excellent Poster Paper Award (Taiwan Lactic Acid Bacteria Association Annual Meeting and Symposium - Prospective Research on Lactic Acid Bacteria - New Perspectives on Next-Generation Health Care, December 2022)
• Graduate student Yang Yachun won the Outstanding Graduate Paper Award (National Cheng Kung University School of Medicine Annual Research Day, May 2022)
• Graduate student Hsu Ya-ting won first place in the poster competition (Taiwan Fisheries Society Annual Meeting, January 2022)
• Graduate student Chen Youzuo won the Excellent Poster Paper Award (Taiwan Lactic Acid Bacteria Association Annual Conference and Symposium - Probiotic Innovation and R&D in the Post-Pandemic Era Symposium, December 2021)
• Graduate student Chen Jiaxiu won the Outstanding Graduate Paper Award (National Cheng Kung University School of Medicine Annual Research Day, May 2021)
• Graduate student Xu Yiyun won the Excellent Poster Paper Award (Taiwan Lactic Acid Bacteria Association Annual Meeting and Symposium - Prospective Applications of Lactic Acid Bacteria Symposium, December 2020)
• The laboratory members include doctoral students, master's students, master's level research assistants, and undergraduate students. Students who are interested in the field of microbiology are welcome to join the team.

Refereed Paper (*Corresponding author)

• Wei-Hsuan Hsu, You-Zuo Chen, Yi-Ting Chiang, Yi-Tsen Chang, Yi-Wen Wang, Kung-Ting Hsu, Yi-Yun Hsu, Pei-Ting Wu, *Bao-Hong Lee. Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs. Nature Communications, 16, 5026, 2025. (2024 Impact factor: 15.7, 5-Year Impact factor: 17.2, Ranking: 10/135=7.4% in Multidisciplinary Sciences)
• #Wei-Leng Chin, #Bao-Hong Lee, Qiao-Yu Hsu, Chih-Yao Hou, Ming-Chyi Pai, Chi-Wei Lin, *Wei-Hsuan Hsu. Small intestine-residing probiotics suppress neurotoxic bile acid production via extracellular vesicle-mediated inhibition of Clostridium scindens. Food Res. Int. 207, 116049, 2025. (2024 Impact factor: 8.0, Ranking: 13/181=7.2% in Food Science & Technology)
• #Tsung-Yu Liu, #Wei-Hsuan Hsu, *Bao-Hong Lee. Evaluation of the application of wild yeasts in inhibiting germination of ochratoxin-producing Fungi during coffee fermentation process. Food Chem. X 25, 102077, 2025. (#Co-first author) (2024 Impact factor: 8.2, Ranking: 11/181=6.1% in Food Science & Technology)
• Bao-Hong Lee, Yi-Ching Lin, Yu-Juan Zheng, Tang-Long Shen, Ting-Yu Cheng, Chih-Chia Huang, *Wei-Hsuan Hsu. Nanoplastics indirectly compromise lettuce growth in hydroponic systems via microbial extracellular vesicles derived from Curvibacter fontanus. J. Hazard. Mater. 480, 136457, 2024. (2023 Impact factor: 12.2, Ranking: 12/358=3.3% in Environmental Sciences)
• Bao-Hong Lee, Yeh-Fang Hu, Sofia Priyadarsani Das, Yu-Ting Chu, *Wei-Hsuan Hsu, *Fan-Hua Nan. An in vitro system mimics the intestinal microbiota of striped Beakfish (Oplegnathus fasciatus) and inhibits Vibrio alginolyticus by Limosilactobacillus reuteri-derived extracellular vesicles. Animals 14, 1792, 2024. (*Co-corresponding author) (2023 Impact factor: 2.3, Ranking: 16/167=9.6% in Environmental Sciences)
• Bao-Hong Lee, Yeh-Fang Hu, Yu-Ting Chu, Yu-Sheng Wu, *Wei-Hsuan Hsu, *Fan-Hua Nan. Lactic acid bacteria-fermented diet containing bacterial extracellular vesicles inhibited pathogenic bacteria in striped beakfish (Oplegnathus fasciatus). Fermentation 10, 49, 2024. (*Co-corresponding author)
• Wei-Jen Chen, Siou-Ru Shen, Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Shan Wei, Hui-Fang Chu, Ming-Chung Tseng, *Tang-Long Shen. Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversity. J. Food Drug Anal. 33, 61-74, 2024.
• Bao-Hong Lee, You-Zuo Chen, Tang-Long Shen, Tzu-Ming Pan, *Wei-Hsuan Hsu. Proteomic characterization of extracellular vesicles derived from lactic acid bacteria. Food Chem. 427, 136685, 2023. (2024 Impact factor: 9.8, Ranking: 4/112=3.6% in Nutrition & Dietetics)
• Bao-Hong Lee, Cheng-Hao Huang, Tsung-Yu Liu, Jung-Shiang Liou, Chih-Yao Hou, *Wei-Hsuan Hsu. Microbial diversity of anaerobic-fermented coffee and potential for inhibiting ochratoxin-produced Aspergillus niger. Foods 12, 2967, 2023. (2024 Impact factor: 5.1, Ranking: 42/181=23.2% in Food Science & Technology)
• Bao-Hong Lee, Shih-Ching Huang, Chih-Yao Hou, You-Zuo Chen, Yu-Hsin Chen, Sulfath Hakkim Hazeena, *Wei-Hsuan Hsu. Effect of polysaccharide derived from dehulled adlay on regulating gut microbiota and inhibiting Clostridioides difficile in an in vitro colonic fermentation model. Food Chem. 410, 135410, 2023. (2024 Impact factor: 9.8, Ranking: 4/112=3.6% in Nutrition & Dietetics)
• Bao-Hong Lee, Kung-Ting Hsu, You-Zuo Chen, You-Lin Tain, Chih-Yao Hou, Yong-Chong Lin, *Wei-Hsuan Hsu. Polysaccharide extracts derived from defloration waste of fruit pitaya regulates gut microbiota in a mice model. Fermentation 8, 108, 2022.
• Chiung-Yu Lai, Chih-Yao Hou, Pei-Ting Chuang, *Wei-Hsuan Hsu, *She-Ching Wu. Microbiota and mycobiota of soy sauce-supplied lactic acid bacteria treated with high pressure. Fermentation 8, 338, 2022. (*Co-corresponding author)
• Le-Ming Wang, Bao-Hong Lee, Chih-Yao Hou, *Wei-Hsuan Hsu, *Chen-Jei Tai. Probiotics-derived extracellular vesicles protect oxidative stress against H₂O₂ induction in placental cells. Fermentation 8, 74, 2022. (*Co-corresponding author)
• Bao-Hong Lee, She-Ching Wu, Tang-Long Shen, Yi-Yun Hsu, Chia-Hsiu Chen, *Wei-Hsuan HsuThe applications of Lactobacillus plantarum-derived extracellular vesicles as a novel natural antibacterial agent for improving quality and safety in tuna fish. Food Chem. 340, 128104, 2021. (2021 Impact factor: 9.2)
• Bao-Hong Lee, Chia-Hsiu Chen, Yi-Yun Hsu, Pei-Ting Chuang, Ming-Kuei Shih, *Wei-Hsuan Hsu.Polysaccharides obtained from Cordyceps militaris Alleviating hyperglycemia by regulating gut microbiota in mice fed a high-fat/sucrose diet. Foods 10, 1870, 2021.
• Bao-Hong Lee†, Wei-Hsuan Hsu†, You-Zuo Chen, Kung-Ting Hsu, Tzu-Ming Pan*. Limosilactobacillus fermentum SWP-AFFS02 improves the growth and survival rate of white shrimp via regulating immunity and intestinal microbiota. Fermentation 7, 179, 2021. (†Co-first author)
• Bao-Hong Lee, Wei-Hsuan Hsu, Chih-Yao Hou, Hao-Yuan Chien, *She-Ching Wu. The protection of lactic acid bacteria fermented-mango peel against neuronal damage induced by amyloid-beta. Molecules 26, 3503, 2021.
• Bao-Hong Lee, Wei-Hsuan Hsu, Hao-Yuan Chien, Chih-Yao Hou, Ya-Ting Hsu, You-Zuo Chen, *She-Ching Wu. Applications of Lactobacillus acidophilus-fermented mango protected Clostridioides difficile infection and developed as an innovative probiotic jam. Foods 10, 1631, 2021.
• Bo-Rui Chen, Kung-Ting Hsu, Wei-Hsuan Hsu, Bao-Hong Lee, Tsung-Lin Li, Yi-Lin Chan, *Chang-Jer Wu. Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus Ameliorates atopic dermatitis symptoms. Int. J. Biol. Macromol. 189, 537-543, 2021.
• Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, *You-Lin Tain. Early-life origins of metabolic syndrome: Mechanisms and preventive aspects. Int. J. Mol. Sci. 22, 11872, 2021. (Review)
• Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, *You-Lin Tain. Cardiovascular diseases of developmental origins: Preventive aspects of gut microbiota-targeted therapy. Nutrients 13, 2290, 2021. (Review)
• Ming-Kuei Shih, You-Lin Tain, Yu-Wei Chen, Wei-Hsuan Hsu, Yao-Tsung Yeh, Sam KC Chang, Jin-Xian Liao, *Chih-Yao Hou. Resveratrol butyrate esters inhibit obesity caused by perinatal exposure to bisphenol A in female offspring rats. Molecules 26, 4010, 2021.
• Bao-Hong Lee, Wei-Hsuan Hsu, Cheng-Hui Lin. The anti-bacterial and anti-adherent effects of Pentraxin-3 on porcine kidney epithelial PK15 cells against Staphylococcus aureus Int. J. Pept. Res. Ther. 25, 645-652, 2019.
• Wei-Hsuan Hsu, Yu-Chun Lin, Bo-Rui Chen, *She-Ching Wu, *Bao-Hong Lee. The neuronal protection of a zinc-binding protein isolated from oyster. Food Chem. Toxicol. 114, 61-68, 2018.
• Liang-Tzung Lin, Ying-Jang Lai, She-Ching Wu, *Wei-Hsuan Hsu, *Chen-Jei Tai. Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer. J. Food Drug Anal. 26, 135-144, 2018. (*Co-corresponding author)
• Wei-Hsuan Hsu, Ying-Jang Lai, *She-Ching Wu. Effects of the anti-microbial peptide pardaxin plus sodium erythorbate dissolved in different gels on the quality of Pacific white shrimp under refrigerated storage. Food Control 73, 712-719, 2017.
• Rui Zhang, Sherri Y. Huang, Kay Ka-Wai Li, Yen-Hsing Li, Wei-Hsuan Hsu, GuangJun Zhang, Chun-Ju Chang, *Jer-Yen Yang. Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget 8, 49869-49881, 2017.
• Chia-Woei Wang, Wei-Hsuan Hsu, *Chen-Jei Tai. Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor α in human ovarian carcinoma cells. Oncotarget 8, 3049-3058, 2017.
• Yeu-Ching Shi, Kai-Sian Lin, Yi-Fen Jhai, Bao-Hong Lee, Yifan Han, Zhibin Cui, *Wei-Hsuan Hsu, *She-Ching Wu. Miracle fruit (Synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent. Molecules 21, 140, 2016. (*Co-corresponding author)
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. 2015. Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation. Int. J. Obes. 39, 1750-1756.
• Yifan Han, Zhibin Cui, Yen-Hsing Li, *Wei-Hsuan Hsu, *Bao-Hong Lee. In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma. Mar. Drugs 14, 2, 2015. (*Co-corresponding author)
• Yu-Ying Chang, Wei-Hsuan Hsu, *Tzu-Ming Pan. Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells. J. Agric. Food Chem. 63, 192-199, 2015.
• ^#Ya-Yun Tan, ^#Wei-Hsuan Hsu, Tsung-Wei Shih, Chih-Hui Lin, *Tzu-Ming Pan. Proteomic insight into the effect of ethanol on citrinin biosynthesis pathway in Monascus purpureus NTU 568. Food Res. Int. 64, 733-742, 2014. (^#Co-first author)
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Monascin attenuates oxidative stress-mediated lung inflammation via peroxisome proliferator-activated receptor-gamma (PPAR-γ) and nuclear factor-erythroid 2 related factor 2 (Nrf-2) modulation. J. Agric. Food Chem. 62, 5337-5344, 2014.
• Wei-Hsuan Hsu, *Tzu-Ming Pan. Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus Appl. Microbiol. Biotechnol. 98, 4853-4863, 2014. (Review)
• Wei-Hsuan Hsu, *Tzu-Ming Pan. A novel PPARgamma agonist monascin potentially applied in diabetes prevention. Food Funct. 5, 1334-1340, 2014. (Review)
• Wei-Hsuan Hsu, Tin-Hong Chen, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. 2014. Monascin and ankaflavin act as natural AMPK activators with PPAR agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem. Toxicol. 64, 94-103, 2014.
• Wei-Hsuan Hsu, Si-Shi Lu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice. Food Funct. 4, 1742-1750, 2013.
• ^#Bao-Hong Lee, ^#Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs). Food Chem. Toxicol. 62, 413-419, 2013. (^#Co-first author)
• Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Appl. Pharmacol. 272, 842-851, 2013.
• Wei-Hsuan Hsu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Inhibition of Th2 cytokine production in T cells by monascin via PPAR‑γ activation. Agric. Food Chem. 61, 8126-8133, 2013.
• Wei-Hsuan Hsu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Peroxisome proliferator-activated receptor-γ activators monascin and rosiglitazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced glycation end products signaling. Agric. Food Chem. 61, 6873-6879, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into D-lactic acid. Free Radic. Biol. Med. 60, 7-16, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Tao Huang, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mic Food Funct. 4, 950-959, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells. Funct. Foods 5, 642-650, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Tao Huang, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated Wistar rats. Agric. Food Chem. 61, 1288-1298, 2013.
• Wei-Hsuan Hsu, Yu-Chun Huang, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. The improvements of ankaflavin isolated from Monascus-fermented products on dyslipidemia in high-fat diet-induced hamster. Funct. Foods 5, 434-443, 2013.
• Wei-Hsuan Hsu, Te-Han Liao, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. Funct. Foods 5, 124-132, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Yu-Ying Chang, Hsuan-Fu Kuo, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin: a natural novel PPARγ against up-regulated Nrf2 to attenuate methylglyoxal (MG)-induced diabetes in vivo. Free Radic. Biol. Med. 53, 2008-2016, 2012.
• Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Chun Huang, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation. Free Radic. Biol. Med. 53, 1643-1651, 2012.
• Bao-Hong Lee, Wei-Hsuan Hsu, Te-Han Liao, *Tzu-Ming Pan. Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation. Food Funct. 3, 758-764, 2012.
• Wei-Hsuan Hsu, Bao-Hong Lee, Te-Han Liao, Ya-Wen Hsu, *Tzu-Ming Pan. Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes. Food Chem. Toxicol. 50, 1178-1186, 2012.
• Wei-Hsuan Hsu, *Tzu-Ming Pan. Monascus purpureus-fermented products and oral cancer: a review. Microbiol. Biotechnol. 93, 1831-1842, 2012. (Review)
• Wei-Hsuan Hsu, Bao-Hong Lee, I-Jen Lu, *Tzu-Ming Pan. Ankaflavin and monascin regulate endothelial adhesion molecules and eNOS expression induced by TNF-α in human umbilical vein endothelial cells (HUVECs). Agric. Food Chem. 60, 1666-1672, 2012.
• Bao-Hong Lee, Wei-Hsuan Hsu, Te-Han Liao, *Tzu-Ming Pan. The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPAR-γ phosphorylation in C2C12 myotubes. Food Chem. Toxicol. 49, 2609-2617, 2011.
• Chin-Feng Liu, Kuo-Chuan Tseng, Shen-Shih Chiang, Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Immunomodulatory and antioxidant potential of Lactobacillus J. Sci. Food Agric. 91, 2284-2291, 2011.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem. Toxicol. 49, 1292-1297, 2011.
• Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Inhibitory effects of dioscorea polysaccharide on TNF-α induced insulin resistance in the mouse FL83B cells. J. Agric. Food Chem. 59, 5279-5285, 2011.
• Chin-Feng Liu, Yi-Ting Tung, Cheng-Lun Wu, Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats. J. Agric. Food Chem. 59, 4537-4543, 2011.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells. J. Sci. Food Agric. 90, 2709-2715, 2010.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidant potentials. Agric. Food Chem. 58, 6715-6720, 2010.

Special Book/Magazine invitation

• Xu Weixuan. Current Status and Future Development Trends of Probiotics in Functional Foods. Biotechnology Special Issue, Food Information Magazine. 16-20, 2021.
• Xu Weixuan and Wu Peiting. Development of a health product combining lactic acid bacteria and Cordyceps militaris for improving metabolic diseases and intestinal flora in elderly pets. Agricultural Biotechnology Industry Quarterly, Vol. 62, pp. 22-26, 2021.
• Xu, Weixuan. Potential of targeting the gut microbiome for Alzheimer’s disease therapy. National Cheng Kung University Research and Development Newsletter, Vol. 32, No. 2, 5, 2020.
• Wei-Hsuan Hsu, Tzu-Ming Pan. 2014. Applications of Monascus-Fermented Products, Encyclopedia of Food Microbiology, Editor: Martinkova L and Patakova P, volume 2: pp. 1481-1487, Elsevier Publishers, Ltd.
• Wei-Hsuan Hsu, Tzu-Ming Pan. 2010. A Novel Adjuvant Therapeutic Material: Chemoprevention of Monascus-Fermented Product on Oral Cancer, In: Oral Cancer: Causes, Diagnosis and Treatment, Chapter IX, ISBN 978-1-61209-305-5, Editor: Michael K. Harris (Ed.), pp. 233-252, Nova Science Publishers, Inc.

 International Symposium Papers

• Bao-Hong Lee, Yu-Wei Chen, Chih-Yao Hou, *Wei-Hsuan Hsu2025. Exploring the role of pineapple derived microRNAs in modulating lactic acid bacteria (probiotics) growth through extracellular vesicles. International Conference on Lactic Acid Bacteria (ICLAB) (Tokyo, Japan).
• Xiao-Yang Chu, Hui-Chun Lin, Cheng-Hao Huang, Shu-Hua Yang, Hung-Hsu Wu, Bao-Hong Lee, *Wei-Hsuan Hsu. 2025. The potential of next-generation probiotics on inhibiting opportunistic bacterium. 15^th Asian Conference on Lactic Acid Bacteria (ACLAB) (Taipei, Taiwan).
• Cheng-Hao Huang, I-Hong Pan, Hsin-Jan Yao, Kuei-Chang Li, Kai-An Chang, Hung-Hsu Wu, Xiao-Yang Chu, Shu-Hua Yang, Bao-Hong Lee, *Wei-Hsuan Hsu. 2025. Gut microbiota and neuroactive metabolite modulation by a probiotic formulation in a human intestinal microbial simulator. 15^th Asian Conference on Lactic Acid Bacteria (ACLAB) (Taipei, Taiwan).
• Shu-Hua Yang, Cheng-Hao Haung, I-Hong Pan, Kuei-Chang Li, Xiao-Yang Chu, Bao-Hong Lee, Yi -Wen Wang, *Wei-Hsuan Hsu. 2025. Probiotic mixture enhances spatial memory via gut-brain axis modulation in mice. 15^th Asian Conference on Lactic Acid Bacteria (ACLAB) (Taipei, Taiwan).
• Wei-Hsuan Hsu, Xiao-Yang Chu, Pin-Hsuan Su, Cheng-Hao Huang, *Bao-Hong Lee. 2025. The protective potential of intestinal Bifidobacterium derived extracellular vesicles with unique lipid composition against blue light-induced damage in retinal cells. 15^th Asian Conference on Lactic Acid Bacteria (ACLAB) (Taipei, Taiwan).
• Wei-Hsuan Hsu, Shu-Hua Yang, Hao-Yuan Chien, Cheng-Hao Huang, Tzu-Ming Pan, *Bao-Hong Lee. 2025. Development of an in vitro culture system for simulating the shrimp gut microbiota and application in investigating the regulation of microbial communities by probiotic-derived extracellular vesicles. 15^th Asian Conference on Lactic Acid Bacteria (ACLAB15) (Taipei, Taiwan).
• Ching-Chang Lee, Tomohiko Yanagawa, Wei-Hsuan Hsu, Wei-Hsiang Chang. 2025. Investigation of Microplastic Accumulation in Freshwater and Aquaculture Fish from Taiwan. 56^th The Asia Pacific Academic Consortium for Public Health Conference (ASPACPH2025) (Chiang Rai, Thailand).
• Wan-Yu Shao, Chia-Chia Lee, Jin-Seng Lin, *Wei-Hsuan Hsu. 2025. The extracellular vesicles of lactic acid bacteria for preventing testosterone-induced hair loss. Asia Pacific Societies for Extracellular Vesicles 2025 (APSEV2025) (Singapore).
• Bao-Hong Lee, Tang-Long Shen, *Wei-Hsuan Hsu. 2025. Nanoplastics indirectly compromise lettuce growth in hydroponic systems via microbial extracellular vesicles derived from Curvibacter fontanus. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• #Wen-Yu Liu, #Bao-Hong Lee, Chia-Hsiu Chen, Tang-Long Shen, You-Zuo Chen, *Wei-Hsuan Hsu. 2025. Harnessing the unique lipid composition and small RNA-delivery capacity of probiotic Pediococcus acidilactici-derived extracellular vesicles suppress spore germination of Clostridioides difficile and opportunistic infection. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria). (^#Co-first author)
• Bao-Hong Lee, Tang-Long Shen, Yi-Wen Wang, Tzu-Hsiang Lin, Shu-Hua Yang, *Wei-Hsuan Hsu. 2025. Impact of extracellular vesicles from food preservative-resistant yeast on the host intestinal environment. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Chih-Yao Hou, Yu-Wei Chen, Bao-Hong Lee, *Wei-Hsuan Hsu. 2025. Intestinal Lactobacillus johnsonii-derived extracellular vesicles suppress Clostridium scindens abundance and reduce toxic bile acid production. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Hui-Chun Lin, Bao-Hong Lee, Tang-Long Shen, Xiao-Yang Chu, Yi-Wen Wang, Ya-Chun Yang, *Wei-Hsuan Hsu. 2025. The interaction between host and gut next-generation probiotics via extracellular vesicles in Alzheimer's disease. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Invited talk: Using bacterial extracellular vesicles to combat Alzheimer's disease through microbiota interactions. 2024. 1st Symposium on Microbiome and Microbiome-Based Therapeutics (SMMT) (Taoyuan, Taiwan).
• Invited talk: Biomedical applications of extracellular vesicles derived from probiotics. 2024. The 3rd Asia Pacific Workshop and Conference on Molecular Medicine (Tainan, Taiwan).
• Shu-Hua Yang, Yi -Wen Wang, Tang-Long Shen, Tzu-Hsiang Lin, *Bao-Hong Lee, *Wei-Hsuan Hsu. 2024. Impact of extracellular vesicles from food preservative-resistant yeast on host gut barrier integrity and inflammatory response. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Xiao-Yang Chu, Tang-Long Shen, Lichieh Julie Chu, Chen-Chien Yang, *Bao-Hong Lee, *Wei-Hsuan Hsu. 2024. Cargo characterization of next-generation probiotic-derived extracellular vesicles via multiomics analysis. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Bao-Hong Lee, Yi-Tsen Chang, You-Zuo Chen, *Wei-Hsuan Hsu. 2024. Explore food microbes with preservative tolerance to spread of antimicrobial resistance from perspective of extracellular vesicles. ISEV 2024 annual Meeting (International Society for Extracellular Vesicles) (Melbourne, Australia).
• Bao-Hong Lee, Yi-Tsen Chang, Hui-Chun Lin, You-Zuo Chen, Tang-Long Shen, *Wei-Hsuan Hsu2024. Exploring the extracellular vesicles derived from food spoilage microorganisms in the transmission of antibiotic resistance and potential impact on the gut environment. ISEV 2024 annual Meeting (International Society for Extracellular Vesicles) (Melbourne, Australia).
• Invited talk: Unveiling the Microbiota Crosstalk: The Role of Bacterial Extracellular Vesicles in Microbiota Interactions. 2023. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Yi-Tsen Chang, You-Zuo Chen, Bao-Hong Lee, *Wei-Hsuan Hsu. 2023. Examining the mechanisms of extracellular vesicles derived from food spoilage microorganisms in transition of antibiotic resistance. Multiomics and Precision Medicine Joint Conference- Omics lights up precision medicine (Taipei, Taiwan).
• Shih-Ching Huang, Bao-Hong Lee, Yi-Tsen Chang, Pin-Hsuan Su, *Wei-Hsuan Hsu. Apr. 2023. Exploring the potential and mechanism of feces-derived extracellular vesicles on improving inflammatory bowel disease. International Microbiome Conference on Precision Health Research and Technology Development & the 6th Annual Conference of Taiwan Microbiota Consortium. Taipei, Taiwan.
• Invited talk: Role of probiotic-derived extracellular vesicles on host and microbiota interaction. 2022. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Tomohiko Yanagawa, Bao-Hong Lee, *Wei-Hsuan Hsu. 2022. Investigating the presence of microscopic plastics released from food containers. 2022iSNST-International Symposium on Novel and Sustainable Technology (Tainan, Taiwan).
• Ya-Chun Yang, Bao-Hong Lee, *Wei-Hsuan Hsu. 2022. Exploring the potential of next generation probiotics on alleviating the symptoms of Alzheimer's disease. International Conference on Application and Marketing of Health Food Materials (Taichung, Taiwan)
• Invited talk: Application of bacterial extracellular vesicles on Alzheimer's disease. 2021. Multiomics and Precision Medicine Joint Conference (Online).
• Bao-Hong Lee, Yi-Ting Chiang, Ming-Chi Fan, Kun-Wei Chan, Jen-Yuan Ju, She-Ching Wu, *Wei-Hsuan Hsu. 2020. Development of lactic acid bacteria combined with Cordyceps species to health products for improving metabolic syndrome and gut microbiota in elderly pet. International Symposium on Development of New Nutraceutical Functions and Ingredients (Online).
• Invited talk: Development and application of extracellular vesicles derived from probiotics. 2020. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Invited talk: Associations and potentials for gut microbiota therapies in Alzheimer's disease. 2020. TSfN2020-Interdisciplinary Neuroscience Congress (Taiwan Society for Neuroscience) (Taipei, Taiwan).
• Bao-Hong Lee, Yi-Ting Chiang, Ming-Chi Fan, Kun-Wei Chan, Jen-Yuan Ju, She-Ching Wu, *Wei-Hsuan Hsu. 2020. Development of lactic acid bacteria combined with Cordyceps species to health products for improving metabolic syndrome and gut microbiota in elderly pet. International Symposium on Development of New Nutraceutical Functions and Ingredients. (Online).
• Wei-Hsuan Hsu, Ko-Chien Chen, Tang-Long Shen. 2018. Lactobacillus plantarum-derived extracellular vesicles improved the quality and safety of tuna meat. ISEV 2018 annual Meeting (International Society for Extracellular Vesicles) (Barcelona, Spain).
• Bao-Hong Lee, Wei-Hsuan Hsu, Tang-Long Shen. 2018. Impact of pathogenic microbes and healthy microbiota by Lactobacillus-derived extracellular vesicles. ISEV 2018 annual Meeting (International Society for Extracellular Vesicles) (Barcelona, Spain).
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. 2012. Monascus-fermented product monascin acts as a novel PPAR-γ ligand to suppress histamine-induced Th2 cytokines production thereby exerting anti-allergic activity. The ISEKI (Integrating Food Science and Engineering Knowledge Into the Food Chain)-Food Association (IFA) (Palmerston North, New Zealand).

• TTQAS Annual Meeting of the Taiwan Society of Inspection and Quality Assurance - Keynote Speech at the Forum on Application of Probiotics and Exosomes in the Health Industry (September 2025)
• Special Lecture at the Taiwan University of Science and Technology Outstanding Young Scholars Camp (September 2025)
• Panelist at the National Taiwan University of Political Science and Law's New Teacher Professional Knowledge Training Camp Forum (September 2025)
• Keynote Speaker- Asia Pacific Societies for Extracellular Vesicles Conference (APSEV) (Singapore) (2025/07)
• Keynote speech at the 63rd Taiwan Agricultural Chemistry Society Symposium (June 2025)
• Keynote Lecture at the Institute of Microbiology and Immunology, National Cheng Kung University (December 2024)
• Keynote speech at the Academic Seminar on Research and Development of Antrodia Cinnamomea, Natural Products and Probiotics (2024/10)
• Keynote Speech at the Taiwan Institute of Inspection and Quality Assurance (TTQAS) Annual Meeting - Innovative Development and Sustainable Development of Healthy Foods Seminar (October 2024)
• International Symposium Keynote Speech - 1st Symposium on Microbiome and Microbiome-Based Therapeutics (SMMT) (2024/10)
• Bacteriology Symposium Keynote Lecture (2024/08)
• International Symposium Keynote Speech - The 3rd Asia Pacific Workshop and Conference on Molecular Medicine (2024/06)
• International Society Lecture - The Malaysian Society for Extracellular Vesicles (MySEV) (2024/05)
• Keynote Speech at the 8th Asia Microbiome Conference (January 2024)
• International Symposium Keynote Speech - Multiomics and Precision Medicine Joint Conference (2023/11)
• National Cheng Kung University Museum Lecture - Sustainable Women Scientists (2023/10)
• TDA/TSID Regenerative Medicine Forum (2023/10)
• TTQAS Taiwan Institute of Inspection and Quality Assurance Annual Meeting - Health Food Development and Processing Technology Seminar for Different Dosage Forms (October 2023)
• Taiwan Microbial Alliance Annual Academic Conference - Keynote Speech at the Symposium on New Prospects in Microbiota Research - Frontiers of Microbiota Research: Dermatology, Metabolomics, Bioinformatics Science (2023/08)
• A New Revolution in Intestinal Health - Special Lecture on the Trend of Precision Application of Probiotics in the World (May 2023)
• Keynote Speech at the 112th Taiwan Medical Association Academic Lecture Conference (May 2023)
• National Taiwan University Joint Lecture on Environmental, Occupational and Food Safety (2023/04)
• Keynote Speech at the Chemistry Annual Conference and Symposium (March 2023)
• International Symposium Keynote Speech - Multiomics and Precision Medicine Joint Conference (2022/11)
• Keynote Speech at the Taiwan Microbial Alliance Annual Academic Conference - Microbial Precision Medicine Next Generation Seminar (2022/08)
• Bacteriology Symposium Keynote Lecture (2022/08)
• MiTalk Young Scientist Workshop Keynote Lecture (January 2022)
• Keynote Speech at the 5th Asia Microbiome Conference (January 2021)
• International Symposium Keynote Speech - Multiomics and Precision Medicine Joint Conference (2021/11)
• Taiwan Lactic Acid Bacteria Association Annual Meeting - Seminar on Prospective Applications of Lactic Acid Bacteria (2020/12)
• International Symposium Keynote Speech - Multiomics and Precision Medicine Joint Conference (2020/11)
• Keynote Speech at the Faculty Forum of National Cheng Kung University Medical School (October 2020)
• International Symposium Keynote Speech - TSfN 2020 Interdisciplinary Neuroscience Congress (2020/09)
• National Cheng Kung University Undergraduate Research UR Future Seminar (2020/08)
• Keynote Lecture by the Dementia Center of National Cheng Kung University Hospital (2020/08)
• Grape King Biotech Co., Ltd. Keynote Speech (2020/08)
• 35th Molecular Biology Summer Camp Young Scholars Experience Forum (2019/08)
• Cross-Strait Food Health Seminar - Youth Forum Keynote Speech (2019/06)
• Speaker at the Interdisciplinary Outstanding Young Scholars Forum (March 2019)