徐瑋萱

• 國立臺灣大學　博士　生化科技學系　2010/09～2013/09
• 國立臺灣大學　碩士　微生物與生化學研究所　2008/09～2010/06
• 國立嘉義大學　學士　食品科學系　2004/09～2008/06

現任

• 國立成功大學 食品安全衛生暨風險管理研究所  副教授   2023 ~
• 台灣胞外體學會理事  2020~
• 國科會計畫審查委員 2019~
• 農業部計畫審查委員 2023~
• 地方產業創新研發推動計畫 (地方型SBIR) 審查委員 2023~
• 南科管理局計畫審查委員 2024~

曾任

• International Journal of Molecular Sciences期刊客座編輯       2022~2023
• 國立成功大學 食品安全衛生暨風險管理研究所  助理教授   2018~ 2023
• 工業技術研究院  生醫與醫材研究所  研究員              2015~ 2018
• 美國普渡大學  醫藥科學系  博士後研究員                  2014~ 2015
• 國立臺灣大學  生化科技學系  博士後研究員              2013~ 2014

• 財團法人成杏醫學文教基金會-優秀論文獎 (2024)
• 國家新創獎-學研新創獎 (2024)
• 臺灣綜合大學年輕學者創新研發成果傑出獎 (2024)
• 未來科技獎 (2024)
• International Society for Extracellular Vesicles Scholarship Fellow (2024)
• 永續跨領域整合型計畫北美國立成功大學校友基金會跨領域研究獎勵優良獎 (2024)
• 李國鼎科技與人文講座金質獎 (2023)
• 國立成功大學醫學院2021年度新人最佳論文獎 (2023)
• 國立成功大學高教深耕計畫潛力優秀學者儀器設備補助 (2022)
• 國立成功大學卓越學術研究補助 (2021)
• 國立成功大學新進教師儀器設備使用額度補助 (2021)
• 國立成功大學新進教師科技部專題研究計畫補助 (2021)
• Journal of Food and Drug Analysis 期刊 2019 年 Top 10 高被引用學者 (IF: 6.157) (2020)
• 臺綜大年輕學者創新研究成果獎 (2019)
• 國立成功大學教研人員彈性薪資暨研究獎勵 (2018~至今)
• 科技部年輕學者獎 (2018)
• 國立臺灣大學傑出表現獎 (2012)
• Johnson & Johnson 年度亞洲傑出生物技術研究生論文獎 (2011)

• 一種含有水晶冰花萃取物之組合物可用於改善阿茲海默症或糖尿病造成記憶損傷症狀。國別：臺灣；專利編號：I532489。
• 龍鬚菜科植物之水萃物或其發酵物的應用與治療及/或減緩神經疾病的醫藥組成物及/或健康食品。國別：臺灣；專利編號：I736781。
• Application for water extract of plant of Gracilariaceae or ferment thereof and pharmaceutical composition and/or health food for treating and/or alleviating nervous diseases。
  國別：美國；專利編號：11083762。
• オコノリ科植物の水抽出物またはその発酵体の使用、なびらた神経疾患を治療および/または緩和する医薬組成物および/または健康食品。
  國別：日本；專利編號：特許第6816090號 (P6816090)。

• 研究生楊書驊榮獲 Poster Meri Award (Multiomics and Precision Medicine Joint Conference，2024/11)
• 研究生馮如羿榮獲壁報論文 優良論文獎 (台灣檢驗及品保學會(TTQAS)學術研討會暨會員大會，2024/10)
• 研究生劉宗宇榮獲研究生優秀論文 優等獎 (成大醫學院年度研究日，2024/05)
• 研究生許喬宇榮獲學生優良論文 佳作獎 (台灣乳酸菌協會年會暨研討會-次世代益生菌之大未來，2023/12)
• 研究生張苡岑榮獲 Best Poster Award (多體學及精準醫學聯合會議-Omics lights up precision medicine，2023/11)
• 研究生張苡岑榮獲研究生優秀論文 優等獎 (成大醫學院年度研究日，2023/05)
• 專題生吳昀蓁與楊子怡榮獲台南區科學展覽會 特優獎 (第 63 屆科學展覽會，2023/04)
• 研究助理陳宥佐榮獲優良壁報論文 佳作獎 (台灣乳酸菌協會年會暨研討會-乳酸菌的前瞻性研究-次世代保健之新觀點，2022/12)
• 研究生楊雅淳榮獲研究生優秀論文 佳作獎 (成大醫學院年度研究日，2022/05)
• 研究生許雅婷榮獲壁報論文競賽 第一名 (台灣水產學會年會，2022/01)
• 研究生陳宥佐榮獲優良壁報論文 佳作獎 (台灣乳酸菌協會年會暨研討會-後疫情時代益生菌之創新研發研討會，2021/12)
• 研究生陳佳秀榮獲研究生優秀論文 優等獎 (成大醫學院年度研究日，2021/05)
• 研究生徐翊芸榮獲優良壁報論文 優等獎 (台灣乳酸菌協會年會暨研討會-乳酸菌的前瞻應用研討會，2020/12)

本研究室成員有博士班研究生、碩士班研究生、碩士級研究助理、大學部專題生，歡迎對微生物領域感興趣之同學加入團隊

專書/雜誌邀稿

• 徐瑋萱。益生菌在機能性食品利用現況及未來發展趨勢。生物科技特刊，食品資訊雜誌。16-p.20，2021 年。
• 徐瑋萱、吳佩庭。乳酸菌合併蛹蟲草用於改善老年寵物代謝相關疾病與腸道菌群之保健產品開發。農業生技產業季刊，第六十二期，22-p.26，2021年。
• 徐瑋萱。以腸道微生物為標靶治療阿茲海默症之潛力。成大研發快訊，第三十二卷，第二期，5，2020年。
• Wei-Hsuan Hsu, Tzu-Ming Pan. 2014. Applications of Monascus-Fermented Products, Encyclopedia of Food Microbiology, Editor: Martinkova L and Patakova P, volume 2: pp. 1481-1487, Elsevier Publishers, Ltd.
• Wei-Hsuan Hsu, Tzu-Ming Pan. 2010. A Novel Adjuvant Therapeutic Material: Chemoprevention of Monascus-Fermented Product on Oral Cancer, In: Oral Cancer: Causes, Diagnosis and Treatment, Chapter IX, ISBN 978-1-61209-305-5, Editor: Michael K. Harris (Ed.), pp. 233-252, Nova Science Publishers, Inc.

國際研討會論文

• Bao-Hong Lee, Tang-Long Shen, *Wei-Hsuan Hsu. 2025. Nanoplastics indirectly compromise lettuce growth in hydroponic systems via microbial extracellular vesicles derived from Curvibacter fontanus. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• #Wein-Yu Liu, #Bao-Hong Lee, Chia-Hsiu Chen, Tang-Long Shen, You-Zuo Chen, *Wei-Hsuan Hsu. 2025. Harnessing the unique lipid composition and small RNA-delivery capacity of probiotic Pediococcus acidilactici-derived extracellular vesicles suppress spore germination of Clostridioides difficile and opportunistic infection. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria). (^#Co-first author)
• Bao-Hong Lee, Tang-Long Shen, Yi-Wen Wang, Tzu-Hsiang Lin, Shu-Hua Yang, *Wei-Hsuan Hsu. 2025. Impact of extracellular vesicles from food preservative-resistant yeast on the host intestinal environment. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Chih-Yao Hou, Yu-Wei Chen, Bao-Hong Lee, *Wei-Hsuan Hsu. Intestinal Lactobacillus johnsonii-derived extracellular vesicles suppress Clostridium scindens abundance and reduce toxic bile acid production. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Hui-Chun Lin, Bao-Hong Lee, Tang-Long Shen, Xiao-Yang Chu, Yi-Wen Wang, Ya-Chun Yang, *Wei-Hsuan Hsu. 2025. The interaction between host and gut next-generation probiotics via extracellular vesicles in Alzheimer’s disease. ISEV 2025 annual Meeting (International Society for Extracellular Vesicles) (Vienna, Austria).
• Invited talk: Using bacterial extracellular vesicles to combat Alzheimer’s disease through microbiota interactions. 2024. 1st Symposium on Microbiome and Microbiome-Based Therapeutics (SMMT) (Taoyuan, Taiwan).
• Invited talk: Biomedical applications of extracellular vesicles derived from probiotics. 2024. The 3rd Asia Pacific Workshop and Conference on Molecular Medicine (Tainan, Taiwan).
• Bao-Hong Lee, Yi-Tsen Chang, You-Zuo Chen, *Wei-Hsuan Hsu. 2024. Explore food microbes with preservative tolerance to spread of antimicrobial resistance from perspective of extracellular vesicles. ISEV 2024 annual Meeting (International Society for Extracellular Vesicles) (Melbourne, Australia).
• Bao-Hong Lee, Yi-Tsen Chang, Hui-Chun Lin, You-Zuo Chen, Tang-Long Shen, *Wei-Hsuan Hsu. 2024. Exploring the extracellular vesicles derived from food spoilage microorganisms in the transmission of antibiotic resistance and potential impact on the gut environment. ISEV 2024 annual Meeting (International Society for Extracellular Vesicles) (Melbourne, Australia).
• Invited talk: Unveiling the Microbiota Crosstalk: The Role of Bacterial Extracellular Vesicles in Microbiota Interactions. 2023. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Yi-Tsen Chang, You-Zuo Chen, Bao-Hong Lee, *Wei-Hsuan Hsu. 2023. Examining the mechanisms of extracellular vesicles derived from food spoilage microorganisms in transition of antibiotic resistance. Multiomics and Precision Medicine Joint Conference- Omics lights up precision medicine (Taipei, Taiwan).
• Invited talk: Role of probiotic-derived extracellular vesicles on host and microbiota interaction. 2022. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Tomohiko Yanagawa, Bao-Hong Lee, *Wei-Hsuan Hsu. 2022. Investigating the presence of microscopic plastics released from food containers. 2022iSNST-International Symposium on Novel and Sustainable Technology (Tainan, Taiwan).
• Ya-Chun Yang, Bao-Hong Lee, *Wei-Hsuan Hsu. 2022. Exploring the potential of next generation probiotics on alleviating the symptoms of Alzheimer’s disease. International Conference on Application and Marketing of Health Food Materials (Taichung, Taiwan)
• Invited talk: Application of bacterial extracellular vesicles on Alzheimer’s disease. 2021. Multiomics and Precision Medicine Joint Conference (Online).
• Bao-Hong Lee, Yi-Ting Chiang, Ming-Chi Fan, Kun-Wei Chan, Jen-Yuan Ju, She-Ching Wu, *Wei-Hsuan Hsu. 2020. Development of lactic acid bacteria combined with Cordyceps species to health products for improving metabolic syndrome and gut microbiota in elderly pet. International Symposium on Development of New Nutraceutical Functions and Ingredients (Online).
• Invited talk: Development and application of extracellular vesicles derived from probiotics. 2020. Multiomics and Precision Medicine Joint Conference (Taipei, Taiwan).
• Invited talk: Associations and potentials for gut microbiota therapies in Alzheimer’s disease. 2020. TSfN2020-Interdisciplinary Neuroscience Congress (Taiwan Society for Neuroscience) (Taipei, Taiwan).
• Bao-Hong Lee, Yi-Ting Chiang, Ming-Chi Fan, Kun-Wei Chan, Jen-Yuan Ju, She-Ching Wu, *Wei-Hsuan Hsu. 2020. Development of lactic acid bacteria combined with Cordyceps species to health products for improving metabolic syndrome and gut microbiota in elderly pet. International Symposium on Development of New Nutraceutical Functions and Ingredients. (Online).
• Wei-Hsuan Hsu, Ko-Chien Chen, Tang-Long Shen. 2018. Lactobacillus plantarum-derived extracellular vesicles improved the quality and safety of tuna meat. ISEV 2018 annual Meeting (International Society for Extracellular Vesicles) (Barcelona, Spain).
• Bao-Hong Lee, Wei-Hsuan Hsu, Tang-Long Shen. 2018. Impact of pathogenic microbes and healthy microbiota by Lactobacillus-derived extracellular vesicles. ISEV 2018 annual Meeting (International Society for Extracellular Vesicles) (Barcelona, Spain).
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. 2012. Monascus-fermented product monascin acts as a novel PPAR-γ ligand to suppress histamine-induced Th2 cytokines production thereby exerting anti-allergic activity. The ISEKI (Integrating Food Science and Engineering Knowledge Into the Food Chain)-Food Association (IFA) (Palmerston North, New Zealand).

期刊論文

• Wei-Leng Chin^†, Bao-Hong Lee ^†, Qiao-Yu Hsu, Chih-Yao Hou, Ming-Chyi Pai, Chi-Wei Lin, *Wei-Hsuan Hsu. Small intestine-residing probiotics suppress neurotoxic bile acid production via extracellular vesicle-mediated inhibition of Clostridium scindens. Food Res. Int. 207, 116049, 2025. (*Corresponding author) (2023 Impact factor: 7.0, Ranking: 11/173=6.3% in Food Science & Technology)
• #Tsung-Yu Liu, #Wei-Hsuan Hsu, *Bao-Hong Lee. Evaluation of the application of wild yeasts in inhibiting germination of ochratoxin-producing Fungi during coffee fermentation process. Food Chem. X 25, 102077, 2025. (#Co-first author) (2023 Impact factor: 6.5, Ranking: 15/173=8.7% in Food Science & Technology)
• Bao-Hong Lee, Yi-Ching Lin, Yu-Juan Zheng, Tang-Long Shen, Ting-Yu Cheng, Chih-Chia Huang, *Wei-Hsuan Hsu. Nanoplastics indirectly compromise lettuce growth in hydroponic systems via microbial extracellular vesicles derived from Curvibacter fontanus. J. Hazard. Mater. 480, 136457, 2024. (*Corresponding author) (2023 Impact factor: 12.2, Ranking: 12/358=3.3% in Environmental Sciences)
• Wei-Jen Chen, Siou-Ru Shen, Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Shan Wei, Hui-Fang Chu, Ming-Chung Tseng, *Tang-Long Shen. Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversity. J. Food Drug Anal. 2024. (Online)
• Bao-Hong Lee, Yeh-Fang Hu, Sofia Priyadarsani Das, Yu-Ting Chu, *Wei-Hsuan Hsu, *Fan-Hua Nan. An in vitro system mimics the intestinal microbiota of striped Beakfish (Oplegnathus fasciatus) and inhibits Vibrio alginolyticus by Limosilactobacillus reuteri-derived extracellular vesicles. Animals 14, 1792, 2024. (*Co-corresponding author) (2023 Impact factor: 2.3, Ranking: 16/167=9.6% in Environmental Sciences)
• Bao-Hong Lee, Yeh-Fang Hu, Yu-Ting Chu, Yu-Sheng Wu, *Wei-Hsuan Hsu, *Fan-Hua Nan. Lactic acid bacteria-fermented diet containing bacterial extracellular vesicles inhibited pathogenic bacteria in striped beakfish (Oplegnathus fasciatus). Fermentation 10, 49, 2024. (*Co-corresponding author)
• Bao-Hong Lee, You-Zuo Chen, Tang-Long Shen, Tzu-Ming Pan, *Wei-Hsuan Hsu. Proteomic characterization of extracellular vesicles derived from lactic acid bacteria. Food Chem. 427, 136685, 2023. (*Corresponding author) (2023 Impact factor: 8.5, Ranking: 4/114=3.5% in Nutrition & Dietetics)
• Bao-Hong Lee, She-Ching Wu, Hao-Yuan Chien, Tang-Long Shen, *Wei-Hsuan Hsu. Tomato-fruit-derived extracellular vesicles inhibit Fusobacterium nucleatum via lipid-mediated mechanism. Food Funct. 14, 8942-8950, 2023. (*Corresponding author) (2023 Impact factor: 5.1, Ranking: 33/173=19.1% in FOOD SCIENCE & TECHNOLOGY)
• Bao-Hong Lee, Cheng-Hao Huang, Tsung-Yu Liu, Jung-Shiang Liou, Chih-Yao Hou, *Wei-Hsuan Hsu. Microbial diversity of anaerobic-fermented coffee and potential for inhibiting ochratoxin-produced Aspergillus niger. Foods 12, 2967, 2023. (*Corresponding author)
• Bao-Hong Lee, Shih-Ching Huang, Chih-Yao Hou, You-Zuo Chen, Yu-Hsin Chen, Sulfath Hakkim Hazeena, *Wei-Hsuan Hsu. Effect of polysaccharide derived from dehulled adlay on regulating gut microbiota and inhibiting Clostridioides difficile in an in vitro colonic fermentation model. Food Chem. 410, 135410, 2023. (*Corresponding author) (2023 Impact factor: 8.5, Ranking: 4/114=3.5% in Nutrition & Dietetics)
• Bao-Hong Lee, Kung-Ting Hsu, You-Zuo Chen, You-Lin Tain, Chih-Yao Hou, Yong-Chong Lin, *Wei-Hsuan Hsu. Polysaccharide extracts derived from defloration waste of fruit pitaya regulates gut microbiota in a mice model. Fermentation 8, 108, 2022. (*Corresponding author)
• Chiung-Yu Lai, Chih-Yao Hou, Pei-Ting Chuang, *Wei-Hsuan Hsu, *She-Ching Wu. Microbiota and mycobiota of soy sauce-supplied lactic acid bacteria treated with high pressure. Fermentation 8, 338, 2022. (*Co-corresponding author)
• Le-Ming Wang, Bao-Hong Lee, Chih-Yao Hou, *Wei-Hsuan Hsu, *Chen-Jei Tai. Probiotics-derived extracellular vesicles protect oxidative stress against H₂O₂ induction in placental cells. Fermentation 8, 74, 2022. (*Co-corresponding author)
• Bao-Hong Lee, She-Ching Wu, Tang-Long Shen, Yi-Yun Hsu, Chia-Hsiu Chen, *Wei-Hsuan Hsu. The applications of Lactobacillus plantarum-derived extracellular vesicles as a novel natural antibacterial agent for improving quality and safety in tuna fish. Food Chem. 340, 128104, 2021. (*Corresponding author) (2021 Impact factor: 9.2)
• Bao-Hong Lee, Chia-Hsiu Chen, Yi-Yun Hsu, Pei-Ting Chuang, Ming-Kuei Shih, *Wei-Hsuan Hsu. Polysaccharides obtained from Cordyceps militaris alleviate hyperglycemia by regulating gut microbiota in mice fed a high-fat/sucrose diet. Foods 10, 1870, 2021. (*Corresponding author)
• Bao-Hong Lee†, Wei-Hsuan Hsu†, You-Zuo Chen, Kung-Ting Hsu, Tzu-Ming Pan*. Limosilactobacillus fermentum SWP-AFFS02 improves the growth and survival rate of white shrimp via regulating immunity and intestinal microbiota. Fermentation 7, 179, 2021. (†Co-first author)
• Bao-Hong Lee, Wei-Hsuan Hsu, Chih-Yao Hou, Hao-Yuan Chien, *She-Ching Wu. The protection of lactic acid bacteria fermented-mango peel against neuronal damage induced by amyloid-beta. Molecules 26, 3503, 2021.
• Bao-Hong Lee, Wei-Hsuan Hsu, Hao-Yuan Chien, Chih-Yao Hou, Ya-Ting Hsu, You-Zuo Chen, *She-Ching Wu. Applications of Lactobacillus acidophilus-fermented mango protected Clostridioides difficile infection and developed as an innovative probiotic jam. Foods 10, 1631, 2021.
• Bo-Rui Chen, Kung-Ting Hsu, Wei-Hsuan Hsu, Bao-Hong Lee, Tsung-Lin Li, Yi-Lin Chan, *Chang-Jer Wu. Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus ameliorates atopic dermatitis symptoms. Int. J. Biol. Macromol. 189, 537-543, 2021.
• Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, *You-Lin Tain. Early-life origins of metabolic syndrome: Mechanisms and preventive aspects. Int. J. Mol. Sci. 22, 11872, 2021. (Review)
• Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, *You-Lin Tain. Cardiovascular diseases of developmental origins: Preventive aspects of gut microbiota-targeted therapy. Nutrients 13, 2290, 2021. (Review)
• Ming-Kuei Shih, You-Lin Tain, Yu-Wei Chen, Wei-Hsuan Hsu, Yao-Tsung Yeh, Sam K. C. Chang, Jin-Xian Liao, *Chih-Yao Hou. Resveratrol butyrate esters inhibit obesity caused by perinatal exposure to bisphenol A in female offspring rats. Molecules 26, 4010, 2021.
• Bao-Hong Lee, Wei-Hsuan Hsu, Cheng-Hui Lin. The anti-bacterial and anti-adherent effects of Pentraxin-3 on porcine kidney epithelial PK15 cells against Staphylococcus aureus Int. J. Pept. Res. Ther. 25, 645-652, 2019.
• Wei-Hsuan Hsu, Yu-Chun Lin, Bo-Rui Chen, *She-Ching Wu, *Bao-Hong Lee. The neuronal protection of a zinc-binding protein isolated from oyster. Food Chem. Toxicol. 114, 61-68, 2018.
• Liang-Tzung Lin, Ying-Jang Lai, She-Ching Wu, *Wei-Hsuan Hsu, *Chen-Jei Tai. Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer. J. Food Drug Anal. 26, 135-144, 2018. (*Co-corresponding author)
• Wei-Hsuan Hsu, Ying-Jang Lai, *She-Ching Wu. Effects of the anti-microbial peptide pardaxin plus sodium erythorbate dissolved in different gels on the quality of Pacific white shrimp under refrigerated storage. Food Control 73, 712-719, 2017.
• Rui Zhang, Sherri Y. Huang, Kay Ka-Wai Li, Yen-Hsing Li, Wei-Hsuan Hsu, GuangJun Zhang, Chun-Ju Chang, *Jer-Yen Yang. Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget 8, 49869-49881, 2017.
• Chia-Woei Wang, Wei-Hsuan Hsu, *Chen-Jei Tai. Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor α in human ovarian carcinoma cells. Oncotarget 8, 3049-3058, 2017.
• Yeu-Ching Shi, Kai-Sian Lin, Yi-Fen Jhai, Bao-Hong Lee, Yifan Han, Zhibin Cui, *Wei-Hsuan Hsu, *She-Ching Wu. Miracle fruit (Synsepalum dulcificum) exhibits as a novel anti-hyperuricaemia agent. Molecules 21, 140, 2016. (*Co-corresponding author)
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. 2015. Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation. Int. J. Obes. 39, 1750-1756.
• Yifan Han, Zhibin Cui, Yen-Hsing Li, *Wei-Hsuan Hsu, *Bao-Hong Lee. In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma. Mar. Drugs 14, 2, 2015. (*Co-corresponding author)
• Yu-Ying Chang, Wei-Hsuan Hsu, *Tzu-Ming Pan. Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells. J. Agric. Food Chem. 63, 192-199, 2015.
• ^#Ya-Yun Tan, ^#Wei-Hsuan Hsu, Tsung-Wei Shih, Chih-Hui Lin, *Tzu-Ming Pan. Proteomic insight into the effect of ethanol on citrinin biosynthesis pathway in Monascus purpureus NTU 568. Food Res. Int. 64, 733-742, 2014. (^#Co-first author)
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Monascin attenuates oxidative stress-mediated lung inflammation via peroxisome proliferator-activated receptor-gamma (PPAR-γ) and nuclear factor-erythroid 2 related factor 2 (Nrf-2) modulation. J. Agric. Food Chem. 62, 5337-5344, 2014.
• Wei-Hsuan Hsu, *Tzu-Ming Pan. Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus Appl. Microbiol. Biotechnol. 98, 4853-4863, 2014. (Review)
• Wei-Hsuan Hsu, *Tzu-Ming Pan. A novel PPARgamma agonist monascin potentially applied in diabetes prevention. Food Funct. 5, 1334-1340, 2014. (Review)
• Wei-Hsuan Hsu, Tin-Hong Chen, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. 2014. Monascin and ankaflavin act as natural AMPK activators with PPAR<alpha> agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem. Toxicol. 64, 94-103, 2014.
• Wei-Hsuan Hsu, Si-Shi Lu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice. Food Funct. 4, 1742-1750, 2013.
• ^#Bao-Hong Lee, ^#Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs). Food Chem. Toxicol. 62, 413-419, 2013. (^#Co-first author)
• Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Appl. Pharmacol. 272, 842-851, 2013.
• Wei-Hsuan Hsu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Inhibition of Th2 cytokine production in T cells by monascin via PPAR‑γ activation. Agric. Food Chem. 61, 8126-8133, 2013.
• Wei-Hsuan Hsu, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Peroxisome proliferator-activated receptor-γ activators monascin and rosiglitazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced glycation end products signaling. Agric. Food Chem. 61, 6873-6879, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into D-lactic acid. Free Radic. Biol. Med. 60, 7-16, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Tao Huang, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mic Food Funct. 4, 950-959, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Ya-Wen Hsu, *Tzu-Ming Pan. Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells. Funct. Foods 5, 642-650, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Tao Huang, Yu-Ying Chang, Ya-Wen Hsu, *Tzu-Ming Pan. Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated Wistar rats. Agric. Food Chem. 61, 1288-1298, 2013.
• Wei-Hsuan Hsu, Yu-Chun Huang, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. The improvements of ankaflavin isolated from Monascus-fermented products on dyslipidemia in high-fat diet-induced hamster. Funct. Foods 5, 434-443, 2013.
• Wei-Hsuan Hsu, Te-Han Liao, Bao-Hong Lee, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. Funct. Foods 5, 124-132, 2013.
• Bao-Hong Lee, Wei-Hsuan Hsu, Yu-Ying Chang, Hsuan-Fu Kuo, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin: a natural novel PPARγ against up-regulated Nrf2 to attenuate methylglyoxal (MG)-induced diabetes in vivo. Free Radic. Biol. Med. 53, 2008-2016, 2012.
• Wei-Hsuan Hsu, Bao-Hong Lee, Yu-Chun Huang, Ya-Wen Hsu, *Tzu-Ming Pan. Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation. Free Radic. Biol. Med. 53, 1643-1651, 2012.
• Bao-Hong Lee, Wei-Hsuan Hsu, Te-Han Liao, *Tzu-Ming Pan. Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation. Food Funct. 3, 758-764, 2012.
• Wei-Hsuan Hsu, Bao-Hong Lee, Te-Han Liao, Ya-Wen Hsu, *Tzu-Ming Pan. Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes. Food Chem. Toxicol. 50, 1178-1186, 2012.
• Wei-Hsuan Hsu, *Tzu-Ming Pan. Monascus purpureus-fermented products and oral cancer: a review. Microbiol. Biotechnol. 93, 1831-1842, 2012. (Review)
• Wei-Hsuan Hsu, Bao-Hong Lee, I-Jen Lu, *Tzu-Ming Pan. Ankaflavin and monascin regulate endothelial adhesion molecules and eNOS expression induced by TNF-α in human umbilical vein endothelial cells (HUVECs). Agric. Food Chem. 60, 1666-1672, 2012.
• Bao-Hong Lee, Wei-Hsuan Hsu, Te-Han Liao, *Tzu-Ming Pan. The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPAR-γ phosphorylation in C2C12 myotubes. Food Chem. Toxicol. 49, 2609-2617, 2011.
• Chin-Feng Liu, Kuo-Chuan Tseng, Shen-Shih Chiang, Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Immunomodulatory and antioxidant potential of Lactobacillus J. Sci. Food Agric. 91, 2284-2291, 2011.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem. Toxicol. 49, 1292-1297, 2011.
• Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Inhibitory effects of dioscorea polysaccharide on TNF-α induced insulin resistance in the mouse FL83B cells. J. Agric. Food Chem. 59, 5279-5285, 2011.
• Chin-Feng Liu, Yi-Ting Tung, Cheng-Lun Wu, Bao-Hong Lee, Wei-Hsuan Hsu, *Tzu-Ming Pan. Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats. J. Agric. Food Chem. 59, 4537-4543, 2011.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells. J. Sci. Food Agric. 90, 2709-2715, 2010.
• Wei-Hsuan Hsu, Bao-Hong Lee, *Tzu-Ming Pan. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. Agric. Food Chem. 58, 6715-6720, 2010.

• Keynote Speaker- Asia Pacific Societies for Extracellular Vesicles Conference (APSEV) (2025/07)
• 國立成功大學微生物與免疫學研究所專題演講 (2024/12)
• 牛樟芝與天然物及益生菌研究開發學術研討會專題演講 (2024/10)
• TTQAS社團法人台灣檢驗及品保學會年會-健康食品的創新開發與永續發展研討會專題演講 (2024/10)
• 國際研討會專題演講-1st Symposium on Microbiome and Microbiome-Based Therapeutics (SMMT) (2024/10)
• 細菌學研討會專題演講 (2024/08)
• 國際研討會專題演講-The 3rd Asia Pacific Workshop and Conference on Molecular Medicine (2024/06)
• 國際學會專題演講-The Malaysian Society for Extracellular Vesicles (MySEV) (2024/05)
• 亞洲微生物體趨勢論壇專題演講- 8th Asia Microbiome Conference (2024/01)
• 國際研討會專題演講- Multiomics and Precision Medicine Joint Conference (2023/11)
• 國立成功大學博物館專題演講- 永續女科學家 (2023/10)
• 皮膚醫學會專題演講- TDA/TSID Regenerative Medicine Forum (2023/10)
• TTQAS社團法人台灣檢驗及品保學會年會-健康食品的開發與不同劑型的加工技術研討會專題演講 (2023/10)
• 台灣微菌聯盟學術年會-微菌研究新展望研討會專題演講-Frontiers of Microbiota research: Dermatology, Metabolomics, Bioinformatics Science (2023/08)
• 腸道健康新革命-全球益生菌精準應用趨勢專題演講 (2023/05)
• 臺灣醫學會 112 年學術演講會專題演講 (2023/05)
• 國立臺灣大學環職食安聯合演講 (2023/04)
• 化學年會暨研討會專題演講 (2023/03)
• 國際研討會專題演講- Multiomics and Precision Medicine Joint Conference (2022/11)
• 台灣微菌聯盟學術年會-微菌精準醫療新世代研討會專題演講 (2022/08)
• 細菌學研討會專題演講 (2022/08)
• MiTalk Young Scientist Workshop 專題演講 (2022/01)
• 亞洲微生物體趨勢論壇專題演講- 5th Asia Microbiome Conference (2021/01)
• 國際研討會專題演講- Multiomics and Precision Medicine Joint Conference (2021/11)
• 台灣乳酸菌協會年會-乳酸菌的前瞻應用研討會專題演講 (2020/12)
• 國際研討會專題演講- Multiomics and Precision Medicine Joint Conference (2020/11)
• 成功大學醫學院教師討論會專題演講 (2020/10)
• 國際研討會專題演講- TSfN 2020 Interdisciplinary Neuroscience Congress (2020/09)
• 成功大學大學部研究 UR Future 座談 (2020/08)
• 成大醫院失智症中心專題演講 (2020/08)
• 葡萄王生技股份有限公司專題演講 (2020/08)
• 35th分子生物夏令營年輕學者經驗座談 (2019/08)
• 海峽兩岸食品健康研討會-青年論壇專題演講 (2019/06)
• 跨領域傑出年輕優秀學者論壇講者 (2019/03)