陳容甄

• 國立成功大學環境醫學研究所/毒理組 博士 2002/09 ~ 2010/06
• 台北醫學大學醫學研究所/基礎組 碩士 1998/09 ~ 2000/06
• 台北醫學大學醫事技術學系 學士 1992/09 ~ 1996/06

工作經歷

• 副教授—國立成功大學食品安全衛生暨風險管理研究所　2022/02 ~ 迄今
• 助理教授—國立成功大學食品安全衛生暨風險管理研究所　2019/0 ~ 2022/01
• 專案助理教授—國立成功大學食品安全衛生暨風險管理研究所　2017/08 ~ 2019/07
• 助理研究學者—國立成功大學/環境醫學研究所　2014/08 ~ 2017/07
• 博士後研究員—台北醫學大學/臨床醫學研究所　2011/08 ~ 2014/07
• 兼任助理教授—嘉南藥理科技大學/化妝品應用管理學系暨研究所　2012/02 ~ 2013/07
• 博士後研究員—國立成功大學/環境醫學研究所　2010/08 ~ 2011/07
• 兼任講師–嘉南藥理科技大學/化妝品應用管理學系　2003/09 ~ 2004/07
• 臨床研究專員—台灣東洋藥品公司/癌症科學發展處臨床研究部　2001/05 ~ 2002/07

專業證照

• 台灣毒物學會認證台灣毒理學家 Certified Toxicologist of Toxicology Society of Taiwan (DTSTA No. 0008, 2018/08/13)　2018
• 教育部助理教授/助理字第145189號　2017
• 食品安全管制系統進階訓練合格證書食安證字第 B1070426059024　 2018
• 食品安全管制系統基礎訓練合格證書食安證字第 A1070402046003 　2018
• 教育部講師/講字第 074982 號　2003
• 醫事檢驗師執照 台檢驗字第 8554 號 (1996/10/04)　1996

專業課程證照

• 國立台灣大學食品科技產業創新課程【保健食品開發課程】　2018
• 毒理學家認證課程結業證明：毒物代謝、農藥毒性、皮膚毒理、基因毒理　2017
• 毒理學家認證課程結業證明：動物與植物毒素的毒性作用、發育毒理學、致癌作用、免疫毒理　2017
• 毒理學家認證課程結業證明：奈米毒理學、職業毒理學、分析及法醫毒理學、空氣汙染　2016
• 毒理學研習課程結業證明：食品安全管理政策新思維、Food Toxicology、Endocrine Disruptors and Toxic Responses of the Endocrine System　2015
• 毒理學家認證課程結業證明：Toxic responses of the reproductive system、Toxic effects of plants and animals、Toxic effects of solvents and vapors　2015
• CRA 臨床試驗專業教育訓練 Basic Monitoring Skill結業證書　2001
• 長庚紀念醫院/中醫藥臨床試驗教育課程結業證書　2001
• 中醫藥委員會/中藥臨床試驗教育訓練結業證書　2001
• 自強工業基金會/新藥臨床試驗、相關法規與 BA/BE 試驗結業證書　2001

• 獲國立成功大學「110年度科技部研究獎勵」。　2021/08~2022/07
• 獲國立成功大學「教研人員彈性薪資暨研究獎勵」。　2020/08~2021/07
• 獲國立成功大學「教研人員彈性薪資暨研究獎勵」。　2020/01~07
• 台灣毒理學家 Certified Toxicologist of Toxicology Society of Taiwan　2018/08~迄今
• 獲國立成功大學110年度新進教師儀器設備使用額補助　2021/06
• 獲國立成功大學110年度員學術研究計畫補助　2021/05
• 獲國立成功大學109年度新進教師暨研究人員學術研究計畫補助　2020/04
• 獲國立成功大學高教深耕計畫「108年新進教師專題計畫補助」　2019/10
• 指導學生獲獎： 2022年成大醫學院研究日優秀論文獎
  Ying-Xuan Huang, Rong-Jane Chen*. Investigation of endocrine disruption and reproductive toxicity induced by food contaminants 3-MCPD and Glycidol.　2022/06/06
• 指導學生獲獎： 2022年成大醫學院研究日優秀論文獎
  Chin-Ching Lu, Rong-Jane Chen*. Study of potential endocrine disruption and reproductive toxicity of food nanoparticles using alternative test methods.　2022/06/06
• 指導學生獲獎：2021年第二屆生態毒理研討會海報論文競賽第一名
  Chia Yu Chang, Rong-Jane Chen*. The silver nanoparticles with different shape triggered-autophagy dysfunction in liver. Chiayi, Taiwan. 2021 Sep 11.　2021/09
• 指導學生獲獎：2021年第二屆生態毒理研討會海報論文競賽第二名
  Siao Shan Lai, Rong-Jane Chen*. Study of the food contaminant 3-monochloro-1,2-propanediol-induced renal toxicity mechanism via toxic mitophagy. Chiayi, Taiwan. 2021 Sep 11.　2021/09
• 指導學生獲獎： 2019年 – 第一屆生態毒理研討會海報論文競賽第一名
  Yu-Ying Chen1, Rong-Jane Chen2, Ying-Jan Wang1,*. Pterostilbene Protects UVB Combined with ZnO Nanoparticles-Induced Skin Damage through Downregulation of Inflammasome and Pyroptosis Activation. Taiwan Ecotoxicity Conference, 08 Jul, 2019, Taoyuan, Taiwan.　2019/07/08
• 指導學生獲獎：2019年 – 第34生物醫學聯合學術年會Best Poster Award：
  Pei-Wen Liu, Rong-Jane Chen*. A study of the mechanism of renal toxicity induced by Co-exposure of food contaminants 3-MCPD and Glycidol. The 34th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 23-24, 2019.　2019/03/24
• 指導學生獲獎：2019年 – 第一屆台灣毒物學學會墾丁冬令營海報論文競賽第一名
  1st winter camp congress of the Taiwan Society of Toxicology, Jan 26-28, 2019.
  得獎論文： Pei-Wen Liu, Rong-Jane Chen, A study of preventive strategy and the mechanism of renal toxicity induced by food contaminants 3-MCPD and Glycidol　2019
• 2017 年：Best Poster Award
  Chen RJ (Presenter). 2017 Taiwan-Korea Conference for Environmental and Occupational Health, February 17-18, 2017
  得獎論文：The urate-lowering effects and urate nephropathy protective mechanisms of pterostilbene by autophagy induction　2017
• 成功大學高引用度論文獎/ HiCi Paper (First Author)
  得獎論文： Chen RJ, Ho YS, Guo HR, Wang YJ. Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Toxicological Science. 2010, 115：118-130. (IF= 5.093. 3.5 % in Toxicology, JCR 2010) (First author)　2013
• 財團法人成杏醫學文教基金會2011年優秀論文獎 (First Author)
  得獎論文： Chen RJ, Ho CT, Wang YJ*. Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells. Mol Nutr Food Res. 54, 1819-1832 (2010) (SCI. IF： 4.713, Ranking： 2/128, Food Science & Technology, JCR 2010)　2012
• 台北醫學院胡水旺獎學金/碩士班第一名　2000

期刊論文

1. Yu-Ying Chen, Yu-Hsuan Lee, Bour-Jr Wang, Rong-Jane Chen*, Ying-Jan Wang*. Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway. Particle and Fibre Toxicology. 2022 Jan 5;19(1):2. doi: 10.1186/s12989-021-00443-w. (MOST 110-2314-B-006 -033 -MY3) (IF=9.112, 4/94=4.2% in Toxicology) (Co-Corresponding author)
2. Rong-Jane Chen, Yi-Jhen Lyu, Yu-Ying Chen, Yen-Chien Lee, Min-Hsiung Pan, Yuan-Soon Ho, Ying-Jan Wang. Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. Molecules 2021 Nov 8;26(21):6741. doi: 10.3390/molecules26216741. (IF=4.927, 36/179=36.3% in CHEMISTRY, MULTIDISCIPLINARY) (First author)
3. Yu-Hsuan Shih, Pei-Jane Tsai, Yen-Lin Chen, Rosita Pranata, Rong-Jane Chen*. Assessment of the Antibacterial Mechanism of Pterostilbene against Bacillus Cereus through Apoptosis-like Cell Death and Evaluation of its Beneficial Effects on the Gut Microbiota. Journal of Agricultural and Food Chemistry 2021 Oct 20;69(41):12219-12229. doi: 10.1021/acs.jafc.1c04898 (MOST 107-2311-B-006 -004 -MY3 and MOST 110-2314-B-006-033-MY3) (IF=5.895, 6/74=8.1% in CHEMISTRY, APPLIED) (Corresponding author)
4. Yu Chi Chen, Rong-Jane Chen*, Szu-Yuan Peng, Winston C Y Yu, Vincent Hung-Shu Chang*. Therapeutic Targeting of Nonalcoholic Fatty Liver Disease by Downregulating SREBP-1C Expression via AMPK-KLF10 axis. Frontiers in Molecular Biosciences 8:751938.doi: 10.3389/fmolb.2021.751938 (MOST 107-2311-B-006 -004 -MY3 and MOST 110-2314-B-006 -033 -MY3) (IF= 6.113, 73/296=24.7% in BIOCHEMISTRY & MOLECULAR BIOLOGY) (Co-Corresponding author)
5. Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang, Rong-Jane Chen*. The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules. 2021 Aug 16;26(16):4954. doi: 10.3390/molecules26164954. (MOST 110-2314-B-006 -033 -MY3) (IF=4.927, 36/179=36.3% in CHEMISTRY, MULTIDISCIPLINARY) (Corresponding author)
6. Rong-Jane Chen, Chiao-Ching Huang, Rosita Pranata, Yu-Hsuan Lee, Yu-Ying Chen, Yuan-Hua Wu, Ying-Jan Wang*. Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. International Journal of Molecular Sciences. 2021 Mar 3;22(5):2536. doi: 10.3390/ijms22052536. (First author). (MOST 107-2311-B-006 -004 -MY3) (IF=6.208, 69/296=23.3% in Biochemistry and Molecular Biology) (First author)
7. Rong-Jane Chen, Yu-Hsuan Leeb, Tzu-Hao Chen, Yu-Ying Chen, Ya-Ling Yeh, Ching-Ping Chang, Chien-Cheng Huang, How-Ran Guo*, Ying-Jan Wang*. Carbon monoxide-triggered health effects: The important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Archives of Toxicology. 2021 Apr;95(4):1141-1159 doi: 10.1007/s00204-021-02976-7 (MOST 107-2311-B-006 -004 -MY3, MOST 108-2638-B-006 -001 -MY2) (IF= 6.168, 9/100=9% in Toxicology) (First author)
8. Pei-Wen Liu, Chung-I Li, Kuo-Ching Huang, Chiang-Shin Liu, Hsiu-Lin Chen, Ching-Chang Lee, Yuan-Yow Chiou, Rong-Jane Chen. 3-MCPD and Glycidol Coexposure Induces Systemic Toxicity and Synergistic Nephrotoxicity via NLRP3 Inflammasome Activation, Necroptosis, and Autophagic Cell Death. Journal of Hazardous Materials. 5 March 2021, 405: 124421, doi.org/10.1016/j.jhazmat.2020.124241 (Corresponding author) (MOST 107-2311-B-006 -004 -MY3, MOST 108-2321-B-006-029, and MOST 109-2321-B-006-014) and Chi Mei Hospital, Liouying Dist, Tainan, Taiwan (CLFHR10812). (IF=14.224, 9/279=3.2% in Environmental Sciences)
9. Wang YJ, Chen YY, Hsiao CM, Pan MH, Wang BJ, Chen YC, Ho CT, Huang KC, Chen RJ. Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition. Frontiers in Cell and Developmental Biology. 2020 Jun 3;8:436. doi: 10.3389 (MOST 107-2311-B-006-004-MY3、Chi Mei Hospital, Liouying Dist, Tainan, Taiwan，CLFHR10731 and CLFHR10812). (IF= 6.081, 6/39=15.4% in Developmental Biology) (Corresponding author)
10. Chen RJ, Chen YY, Liao MY, Lee YH, Chen ZY, Yan SJ, Yeh YL, Yang LX, Lee YL, Wu YH, Wang YJ. The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies. International Journal of Molecular Sciences. 2020, Mar 30;21(7):2387; doi:10.3390/ijms21072387. (MOST 107-2311-B-006-004-MY3) (IF=6.208, 69/296=23.3% in Biochemistry and Molecular Biology) (First author)
11. Lee YH, Chen YY, Yeh YL, Wang YJ, Chen RJ. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. International Journal of Molecular Sciences. 2019, Jun 2;20(11). pii: E2716. doi: 10.3390/ijms20112716. (Corresponding author) (IF=6.208, 69/296=23.3% in Biochemistry and Molecular Biology) (MOST 107-2311-B-006 -004 -MY3)
12. Chen RJ, Kuo HC, Cheng LH, Lee YH, Chang WT, Wang BJ, Wang YJ, Cheng HC. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer. International Journal of Molecular Sciences. 2018 Jan 18;19(1). pii: E287. doi: 10.3390/ijms19010287 (IF=6.208, 69/296=23.3% in Biochemistry and Molecular Biology) (First author)
13. Chen RJ, Wu PH, Ho CT, Way TD, Pan MH, Chen HM, Ho YS, Wang YJ. p53-dependent Down-regulation of hTERT Protein Expression and Telomerase Activity Induces Senescence in Lung Cancer Cells as a Result of Pterostilbene Treatment. Cell Death & Disease. 2017 Aug 10;8(8):e2985. doi: 10.1038/cddis.2017.333 (IF= 705, 35/194=18% in Cell Biology) (First author)
14. Chen RJ, Chen MH, Chen YL, Hsiao CM, Wu PH, Chen HM, Chen SJ, Wu MD, Yech YJ, Yuan GF, Wang YJ. Evaluating the Urate Lowering Effects of Different Microbial Fermented Extracts in a Hyperuricemic Therapeutic and Preventive Animal Model Accompanied with a Safety Study. Journal of Food and Drug Analysis. 2017 Jul, 25(3): 597-606. (IF= 6.157, 42/361=11.6% in PHARMACOLOGY & PHARMACY) (First author)
15. Chen RJ, Lee YH, Yeh YL, Wu WS, Ho CT, Li CY, Wang BJ, Wang YJ. Autophagy-inducing Effect of Pterostilbene: a Prospective Therapeutic/Preventive Option for Skin Diseases. Journal of Food and Drug Analysis. 2017 Jan;25(1):125-133. doi: 10.1016 (IF= 6.157, 42/361=11.6% in PHARMACOLOGY & PHARMACY) (First author)
16. Chen RJ, Lee YH, Yeh YL, Wang YJ, Wang BJ. The Roles of Autophagy and the Inflammasome during Environmental Stress-Triggered Skin Inflammation. International Journal of Molecular Sciences. 2016 Dec 9;17(12). pii: E2063 (IF= 5.923, 67/298=22.4% in Biochemistry and Molecular Biology) (First author)
17. Chen RJ, Wu HH, Wang YJ. Strategies to prevent and reverse liver fibrosis in humans and laboratory animals. Archives of Toxicology. 2015, 89(10):1727-50. (IF= 5.153, 16/93=17.2% in Toxicology) (First author)
18. Chen RJ, Siao SH, Hsu CH, Chang CY, Chang LW, Wu CH, Lin P, Wang YJ. TCDD Promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. PLOS ONE. 2014, 9(6):e99586. (IF= 3.730, 12.5% in Multidisciplinary Sciences) (First author)
19. Chen RJ, Chang CY, Chang LW, Siao SH, Ho YS, Wu CH, Foo NP, Lin P, Wang YJ. The Regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumor Promotion by Estradiol in Female A/J Mice. PLOS ONE. 2014, 9(3):e93152. (IF= 3.730, 12.5% in Multidisciplinary Sciences) (First author)
20. Chen HM, Zhu BZ, Chen RJ, Wang BJ, Wang YJ. The Pentachlorophenol Metabolite Tetrachlorohydroquinone Induces Massive ROS and Prolonged p-ERK Expression in Splenocytes, Leading to Inhibition of Apoptosis and Necrotic Cell Death. PLOS ONE. 2014, 9(2):e89483. (IF= 3.730, 12.5% in Multidisciplinary Sciences)
21. Chen HM, Lee YH, Chen RJ, Chiu HM, Wang BJ, Wang YJ. The immunotoxic effects of dual exposure to PCP and TCDD. Chemico-Biological Interactions. 2013, 206(2): 166-174. (IF=3.296, 25% in Toxicology)
22. Chen RJ, Tsai SJ, Ho CT, Pan MH, Ho YS, Wu CH, Wang YJ. Chemopreventive Effects of Pterostilbene on Urethane-Induced Lung Carcinogenesis in Mice via the Inhibition of EGFR-Mediated Pathways and the Induction of Apoptosis and Autophagy. Journal of Agricultural and Food Chemistry. 2012, 60(46):11533-41. (IF= 3.412, 3% in Agriculture, Multidisciplinary) (First author)
23. Chen RJ, Hung CM, Chen YL, Wu MD, Yuan GF, Wang YJ. Monascuspiloin Induces Apoptosis and Autophagic Cell Death in Human Prostate Cancer Cells via the Akt and AMPK Signaling Pathways. Journal of Agricultural and Food Chemistry. 2012, 60(29): 7185-93. (IF= 3.412, 3% in Agriculture, Multidisciplinary) (First author)
24. Chen RJ, Ho YS, Wu CH, Wang YJ. Molecular Mechanisms of Nicotine-induced Bladder Cancer. Journal of Experimental and Clinical Medicine. 2011, 3:252-256. (IF= 0.06, 3% in Agriculture, Multidisciplinary) (First author)
25. Chen RJ, Chang LW, Lin P, Wang YJ. Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke: An Overview. Journal of Oncology. 2011, 65493. (IF= 4.528, 27% in Oncology, JCR 2017) (First author)
26. Chen RJ, Ho CT, Wang YJ. Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells. Molecular Nutrition & Food Research. 2010, 54:1819-1832. (IF=914, 5%=9/163 in Food Science & Technology, JCR 2020) (First author)
27. Chen RJ, Ho YS, Guo HR, Wang YJ. Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Toxicological Science. 2010, 115:118-130. (IF=093. 3.5 % in Toxicology) (First author)
28. Chen RJ, Ho YS, Guo HR, Wang YJ. Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Toxicological Sciences. 2008, 104:283-293. (IF=093, 3.5 % in Toxicology) (First author)
29. Huang CS, Ho WL, Lee WS, Sheu MT, Wang YJ, Tu SH, Chen RJ, Chu JS, Chen LC, Lee CH, Tseng H, Ho YS, Wu CH. SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: an in vitro and in vivo study. Biochemical Pharmacology. 2008, 75:1783-96. (IF=889, 8 % in Pharmacology & Pharmacy)
30. Cheng TJ, Wang YJ, Kao WW, Chen RJ, Ho YS. Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid. Food and Chemical Toxicology. 2007, 45:1027-38. (IF=977, 7.5 % in Food Science & Technology)
31. Ho YS, Huang PC, Guo HR, Chang WH, Chen RJ. Wei BL, Wu WJ, Tai C, Wang YJ. Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide. Radiation Research. 2006, 165:390-9. (IF=53, 27 % in Biology)
32. Guo HR. Chen Ho SY. Ho YS. Chen RJ. Wang YJ. Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells. International Journal of Radiation Biology. 2006, 82:97-109. (IF= 1.861, 5.9 % in Nuclear Science & Technology)
33. Ho YS, Chen CH, Wang YJ, Pestell RG, Albanese C, Chen RJ. Chang MC, Jeng JH, Lin SY, Liang YC, Tseng H, Lee WS, Lin JK, Chu JS, Chen LC, Lee CH, Tso WL, Lai YC, Wu CH. Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicology & Applied Pharmacology. 2005, 205:133-48. ( IF=616, 21 % in Toxicology)
34. Lee WS, Chen RJ, Wang YJ, Tseng H, Jeng JH, Lin SY, Liang YC, Chen CH, Lin CH, Lin JK, Ho PY, Chu JS, Ho WL, Chen LC, Ho YS. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. International Journal of Cancer. 2003, 106:125-37. (IF=36, 10 % in Oncology)
35. Wang YJ, Jeng JH, Chen RJ, Tseng H, Chen LC, Liang YC, Lin CH, Chen CH, Chu JS, Ho WL, Ho YS. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Molecular Carcinogenesis. 2002, 34: 199-210. (IF=851, 28 % in Biochemistry and Molecular Biology)
36. Ho YS, Duh JS, Jeng JH, Wang YJ, Liang YC, Lin CH, Tseng CJ, Yu CF, Chen RJ, Lin JK. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. International Journal of Cancer. 2001, 91:393-401. (IF=36, 10 % in Oncology, JCR 2010)
37. Chen RJ, Lee WS, Liang YC, Lin JK, Wang YJ, Lin CH, Hsieh JY, Chaing CC, Ho YS. Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines. Toxicology & Applied Pharmacology. 2000, 169:132-41. (IF=616, 21 % in Toxicology)(First author)
38. Ho YS, Liu HL, Duh JS, Chen RJ, Ho WL, Jeng JH, Wang YJ, Lin JK. Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells. Molecular Carcinogenesis. 1999, 26: 201-11. (IF=851, 28 % in Oncology)
39. Ho YS, Tsai PW, Yu CF, Liu HL, Chen RJ. Lin JK. Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines. Toxicology & Applied Pharmacology. 1998, 153:39-47. (IF= 3.616, 21 % in Toxicology)

研討會論文

1. 2022第36屆生物醫學聯合學術年會: Rosita Pranata, Rong-Jane Chen*. Application of alternative methods to assess the genotoxic potential of nanoparticles in food products. The 36th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 26-27.
2. 2022第36屆生物醫學聯合學術年會: Ying-Xuan Huang, Rong-Jane Chen*. Investigation of Endocrine Disruption and Reproductive toxicity Induced by Food Contaminants 3-MCPD and glycidol. The 36th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 26-27.
3. 2022第36屆生物醫學聯合學術年會: Chin-Ching Lu, Rong-Jane Chen*. Study of Potential Endocrine Disruption and Reproductive Toxicity of Food Nanoparticles Using Alternative Testing. The 36th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 26-27.
4. 第二屆生態毒理研討會: (The 2nd Ecotoxicology Conference). Chiayi, Taiwan. 2021 Sep 11. Chia Yu Chang, Rong-Jane Chen*. The silver nanoparticles with different shape triggered-autophagy dysfunction in liver. Chiayi, Taiwan. 2021 Sep 11.
5. 第二屆生態毒理研討會: (The 2^nd Ecotoxicology Conference). Siao Shan Lai, Rong-Jane Chen*. Study of the food contaminant 3-monochloro-1,2-propanediol-induced renal toxicity mechanism via toxic mitophagy. Chiayi, Taiwan. 2021 Sep 11.
6. 第二屆生態毒理研討會 (The 2^nd Ecotoxicology Conference). Yu-Hsuan Lee, Rong-Jane Chen*. Glycidol-induced Renal Toxicity via DNA Damage and Cell Cycle Arrest in vivo and in vitro. Chiayi, Taiwan. 2021 Sep 11.
7. Chen RJ. 台灣兒童腎臟醫學會第七屆學術研討會 (Invited speaker) Renal toxicity induced by food contaminants 3-MCPD and Glycidol. Tainan, Taiwan. May 31, 2020.
8. Chen RJ.,, YH., Antibacterial effects and the mechanisms of pterostilbene against foodborne pathogens. The 7th International Conference on Food Factors (ICoFF 2019), Kobe Convention Center, Japan. Dec 01-05, 2019. (MOST 107-2311-B-006 -004 -MY3)
9. Yi-Hsuan Huang, Rong-Jane Chen., The potential effects/ relative mechanisms and safety study of ent-kaurane diterpenoid extracted from C. tonkinensis Gagnep as an anti-lung cancer agent. The 7th International Conference on Food Factors (ICoFF 2019), Kobe Convention Center, Japan. Dec 01-05, 2019. (MOST 107-2311-B-006 -004 -MY3)
10. 2019 第一屆生態毒理研討: Yu-Ying Chen¹, Rong-Jane Chen², Ying-Jan Wang^1,*. Pterostilbene Protects UVB Combined with ZnO Nanoparticles-Induced Skin Damage through Downregulation of Inflammasome and Pyroptosis Activation. Taiwan Ecotoxicity Conference, 08 Jul, 2019, Taoyuan, Taiwan.
11. 2019 第34屆生物醫學聯合學術年會: Yu-Hsuan Shih , Rong-Jane Chen*. Synergistic Antibacterial Effects of Silver Nanoparticles in Combination with Stilbenoid Compounds Against Bacillus Cereus and Staphylococcus Aureus. The 34^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 23-24, 2019.
12. 2019 第34屆生物醫學聯合學術年會: Pei-Wen Liu, Rong-Jane Chen*. A study of the mechanism of renal toxicity induced by Co-exposure of food contaminants 3-MCPD and Glycidol. The 34^th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. Mar 23-24, 2019.
13. 2019 第34屆生物醫學聯合學術年會: Yu-Ting Chang, Rong-Jane Chen*. Evaluation the Protective Effects of Natural Products against Osteoarthritis via Inactiation of NLRP3 Inflammasome by in vivo and in vitro studies. The 34^th Joint of Annual Conference of iomedical Science, Taipei, Taiwan. Mar 23-24, 2019.
14. Pei-Wen Liu, Rong-Jane Chen*. A study of preventive strategy and the mechanism of renal toxicity induced by food contaminants 3-MCPD and Glycidol. 1^st winter camp congress of the Taiwan Society of Toxicology, Jan 26-28, 2019. Kenting, Taiwan.
15. Yu-Hsuan Shih , Rong-Jane Chen*. The antibacterial effect of the stilbenoid compounds against foodborne pathogens Bacillus cereus and Staphylococcus aureus. 1st winter camp congress of the Taiwan Society of Toxicology, Jan 26-28, 2019. Kenting, Taiwan.
16. Yu-Ying Chen¹, Rong-Jane Chen², Ying-Jan Wang*¹. Pterostilbene Protects UVB Combined with ZnO Nanoparticles-Induced Skin Damage through Downregulation of Inflammasome Activation. 2018 Annual Meeting of Taiwan Society for Mitochondria Research and Medicine-International Symposium of Mitochondrial Medicine and Therapeutics. 2018，October 27, National Tsing Hua University, Hsinchu, Taiwan.
17. Chen RJ., Shih YH., Wang YJ. Synergistic Antibacterial and Antibiofilm Efficacy of Pterostilbene in Combination with Silver Nanoparticles against Food Born Bacteria Yu-Ying Staphylococcus Aureus and Bacillus Cereus. 26^th International ICFMH Conference – FoodMicro 2018，September 3^rd – 6^th 2018, Henry Ford Building, Freie Universität Berlin, Germany. (MOST 107-2311-B-006 -004 -MY3)
18. Chen RJ. Chemopreventive Effects of Pterostilbene against Environmental Toxicants-Induced Carcinogenesis. Gro Brundtland Week of Women in Sustainable Development, 03 April, 2018, Tainan, Taiwan (Invited speaker)
19. Chen YY, Chen RJ, Wang YJ. Pterostilbene Prevents Inflammasome Activation and Apoptosis in Skin Damage Model Induced by UVB Combined with Znic Oxide Nanoparticle. International Conference on Functional Food for improving Sarcopenia, Cachexia and Frailty, 02 Mar, 2018, Taipei, Taiwan.
20. Chen YY, Chen RJ, Wang YJ. Pterostilbene Protects UVB Combined with ZnO Nanoparticles-Induced Skin Damage through Downregulation of Inflammasome Activation. The 33nd Joint Annual Conference of Biomedical Science, 24-25 Mar, 2018, Taipei, Taiwan.
21. Chen RJ, Wang YJ. The urate-lowering effects and urate nephropathy protective mechanisms of pterostilbene by autophagy induction. Asia-Pacific Conference on Life Science and Biological Engineering (APLSBE), 29-31 Mar, 2017, Nagoya, Japan. (First author) (MOST 103-2321-B-006 -019 -MY3)
22. Chen RJ, Wang YJ. The mechanisms of nicotine-induced chemoresistance through Stat3 mediated autophagy and glycolysis in human bladder cancer cells. The 6^th International Congress on Chemical, Biological and Environmental Sciences (ICCBES), 10-12 May, 2016, Osaka, Japan. (First author) (MOST 103-2321-B-006 -019 -MY3)
23. Chen RJ, Lyu YJ, Wang YJ. Pterostilbene Combined with Chloroquine Promotes Pancreatic Cancer Cell Apoptosis through Downregulation of RAGE-STAT3 Mediated Autophagy Pathway. 12^th Asian Congress of Nutrition (ACN), 14-18 May, 2015, Yokohama, Japan. (First author) (MOST 103-2321-B-006 -019 -MY3)
24. Chen RJ, Wang YJ. The Regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Induced Lung Tumor Promotion by Estradiol in Female A/J Mice. 2^nd Annual Academic Conference of International Medical Geology Association, 14 May, 2013, Tainan, Taiwan. (First author)
25. Chen RJ, Hung CM, Wang YJ. Monascuspiloin Inhibits Growth of Human Prostate Cancer Cells and Suppresses Tumor Growth by Inducing Apoptosis and Autophagy. International Symposium on Cell Signaling and Gene Regulation, 19-20 Feb, 2011, Tainan, Taiwan. (First author)
26. Chen RJ, Ho YS, Guo HR, Wang YJ. Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. 18^th Annual Meeting of the International Society for Environmental Epidemiology (ISEE), 2-6 Sep, 2006, Paris, France. (First author)

專書

1. CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, Ch27 Pterostilbene Protection and Bladder Cancer Cells. Wang YJ, Chen RJ. First edition 2014, Copyright © 2014 Elsevier Inc.
2. CANCER (Second Edition): OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, Ch40 – Pterostilbene and cancer chemoprevention. Chen RJ, Wang YJ. 2021, Pages 451-463, Copyright © 2021 Elsevier Inc.

碩士論文

• 抗黴菌藥抑制人類惡性腫瘤細胞生長之分子機制 陳容甄 著 (1999)

博士論文

• 探討尼古丁促進膀胱癌細胞生長與化療抗性的機轉並研究紫檀芪對化療敏感性與尼古丁誘發具化療抗性的膀胱癌細胞之治療效果與機制 陳容甄 著 (2010)
  The proliferative/chemoresistant effects of nicotine in human bladder cancer cells and the anti-cancer effects of pterostilbene in sensitive and chemoresistant bladder cancer cells. 2010

研究計畫

• 科技部：探討粒線體自噬作用在食品汙染物3 – 單氯丙二醇及縮水甘油單獨或合併暴露時誘導內分泌干擾及生殖毒性之機轉 （145萬/年，MOST 110-2314-B-006 -033 -MY3）
  計畫主持人　2021/08/01~2024/07/31
• 科技部： 紫檀芪減緩骨關節炎之機轉研究 – 活化自體吞噬進而抑制NLRP3發炎體調控之細胞焦亡 （1,000,400/年MOST 111-2320-B-006-027-MY2）
  計畫住持人　2022/08/01~2024/07/31
• 科技部： 一般策略專案計畫（整合型） 精準健康之新世代農業： 台灣茶應用在生技產業之基理研究與新品開發－台灣茶應用在生技產業之基理研究與新品開發（多年期1/3），MOST 111-2321-B-005-006 – （3,400,000）
  共同主持人　2022/07/01~2023/06/30
• 應用推展 3Rs 替代測試核心技術協助產業界完成化學物質註冊登錄（1/3） （200萬/年，MOST 111-2622-8-006-014 -TB）
  共同主持人　111/02/01~112/01/31
• 行政院環境保護署毒物及化學物質局委託研究，計畫名稱：多元化學物質高通量風險管理計畫　計畫編號：111A019 （500萬）
  共同主持人　111/2/11~111/11/30
• 111年度部南與成大醫院策略聯盟研究計畫，評估天然物紫檀芪治療肺癌的功效及機轉探討 （TNHPA11016，34萬）
  成大計畫主持人　111/01/01~111/12/31
• 111年度衛生福利部所屬醫院「研究發展獎勵計畫」抑制自體吞噬路徑以促進紫檀芪誘導胰臟癌細胞的細胞凋亡 （11136，351,000元）
  共同主持人　111/01/01~111/11/30
• 110 國立成功大學醫學院暨奇美醫療財團法人奇美醫院學術合作專題研究計畫： 乳癌化學治療藥物與續發性癌症的相關性研究-臺灣全國性的女性世代研究 （30萬/年，MNCKU11007）
  成大計畫主持人　2021/09/01~2022/08/31
• 109 行政院環境保護署毒物及化學物質局委託研究 強化我國化學物質毒性高通量風險預測平臺前期建置計畫（總計畫6,624,118）
  共同主持人　2020/11~2021/11/30
• 109110 衛福部食藥署： 食品中對殺菌物質具抗性微生物之先期研究 MOHW109-FDA-F-114-000375 （87.5萬）
  計畫主持人　2020 02/01~2020/12/31
• 科技部： 沙克爾頓計畫－一氧化碳健康效應的機轉與其應用之研究－經由探索一氧化碳健康效應機轉與應用以提升我國國際學術影響力並輔導年輕學者提升科研能量 （MOST 108-2638-B-006 -001 -MY2） （350萬/年）
  共同主持人　2019/08/01~2021/07/31
• 科技部： 食安整合計畫－食品中縮水甘油脂肪酸酯及單氯丙二醇（酯）檢測技術精進、含量監測、安全及暴露風險評估、管理與溝通研究-子計畫三縮水甘油脂肪酸酯及單氯丙二醇（酯）等污染物毒性安全研究MOST 109-2321-B-006-014 –（子計畫兩年116萬）
  子計畫主持人　2020/07/01~2021/05/31
• 科技部： 食安整合計畫－食品中縮水甘油脂肪酸酯及單氯丙二醇（酯）檢測技術精進、含量監測、安全及暴露風險評估、管理與溝通研究 MOST 108-2321-B-006-029 –（子計畫兩年116萬）
  子計畫主持人　2019/07/01~2020/06/30
• 科技部： 天然物紫檀芪誘發自體吞噬作用以預防高嘌呤飲食及食品汙染物3－單氯丙二醇誘發之腎臟發炎及纖維化 （123萬/年） MOST 107-2311-B-006 -004 -MY3
  計畫主持人　2018/08/01~2021/07/31
• 柳營奇美醫院院內計畫：以高尿酸小鼠模式研究木麻黃素降尿酸之功效及機制 （26萬） CLFHR10834
  共同主持人　2019/07/01~2020/06/30
• 柳營奇美醫院院內計畫： 共同暴露食品汙染物3－單氯丙二醇及縮水甘油誘發之腎臟毒性機轉探討 （38萬） CLFHR10812
  共同主持人　2019/01/01~2019/12/31
• 柳營奇美醫院院內計畫： 探討食品汙染物3－單氯丙二醇及縮水甘油 活化發炎體及細胞凋亡導致腎臟損傷之機轉（32萬） CLFHR10731
  共同主持人　2018/07/01~2019/06/30
• 科技部：研究學者專題研究計畫 （助理研究學者）
  環境毒物尼古丁改變肺癌細胞粒腺體代謝功能而促進人類肺癌細胞產生化療抗性之機轉及預防（100萬/年） MOST 103-2321-B-006 -019 -MY3
  計畫主持人　2014/08/01~2017/07/31

邀請演講

• 2021 1105：高雄醫學大學毒理學碩/博士學位學程（Invited speaker)
  Chen RJ. 食品汙染物單氯丙二醇及縮水甘油之腎臟毒性機轉
• 2020 0721：國家衛生研究院環境醫學研究所（Invited speaker）
  Chen RJ. Co-exposure to 3-MCPD and Glycidol Synergistically Induces Nephrotoxicity via NLRP3 Inflammasome Activation and Programmed Cell Death
• 2020 0531：台灣兒童腎臟醫學會第七屆學術研討會（Invited speaker）
  Chen RJ. Renal toxicity induced by food contaminants 3-MCPD and Glycidol
• 2019 Nov 27：高雄師範大學生物科技系
  Chen RJ. 蔬果食安與毒理學應用。(Invited speaker）
• 2019 Oct 18，台南餐旅教育協會食安講座邀請演講：
  Chen RJ. 估毒的美食家-毒理角度聊食安（Invited speaker）
• 2019 第34屆生物醫學聯合學術年會Mar 23-24, 2019. Taipei, Taiwan
  Chen RJ. Preventive Effects of Pterostilbene against Food Contaminants-Induced Toxicity through Autophagy Induction.（Invited speaker）
• 2018 Gro Brundtland Week of Women in Sustainable Development 03 April, 2018, Tainan, Taiwan Chen RJ. Chemopreventive Effects of Pterostilbene against Environmental Toxicants-Induced Carcinogenesis.（Invited speaker）
• 2017中興大學生物科技研究所，Chen RJ. Pterostilbene Induces Senescence in Lung Cancer Cells through Down-regulation of hTERT Protein Expression and Telomerase Activity. January 16, 2017.

訓練課程授課

• 行政院環境保護署環境保護人員訓練所/毒性化學物質專業技術管理人員訓練（202012月起~）
• 化學物質風險評估教育訓練 2020/11、2021/01（化學局主辦）
• 行政院環境保護署 環境檢驗所 毒理學課程 2018/03
• 奇美醫院放射腫瘤科：輻射生物學 2013，2016

Committee member（委員）

• 台灣毒物學會副秘書長　2022/03/26~迄今
• 衛生福利部食品藥物管理署基因改造食品諮議委員會（諮議委員）　2018/01~迄今
• 中華民國消費者文教基金會雲嘉南分會食品委員會委員　2019/06~迄今
• 行政院環境保護署毒物及化學物質局新化學物質標準登錄審查技術顧問　2019~2021
• 成大醫學院動物管理委員會委員　110年度~
• 台灣毒物學會第一屆冬令營大會秘書　2019/01
• 台灣經濟研究院生物科技產業研究中心，食品安全議題專家諮詢暨消費者調查分析研討座談會（專家委員）　2018/12/07
• 美國在臺協會主辦，財團法人食品工業發展研究所協辦-作物基因編輯之國際應用與政策發展專家座談會（與會專家）　2018 11/2
• 國立成功大學附設醫院院內計畫（評審委員）　2018/09
• 高雄長庚紀念醫院院內計畫（審查委員）　2018/09
• 衛生福利部食品藥物管理署我國消費者基因改造食品認知調查專家諮詢會議（專家委員）　2018/08
• 第三十三屆生物醫學聯合學術年會 壁報論文競賽評審委員　2018/03
• 台中慈濟醫院院內計畫（審查委員）　2018/04

Journal Reviewer

• Antibiotics　2021~
• Cell Communication and Signaling　2021~
• Biomolecules　2020~
• Biomedical Pharmacology　2020~
• Cancers　2020~
• Frontiers in Molecular Biosciences　2021~
• International Journal of Nanomedicine　2020~
• Nutrients　2019~迄今
• Evidence-Based Complementary and Alternative Medicine　2019~迄今
• Marine Drugs　2019~迄今
• International Journal of Molecular Sciences　2018~迄今
• SciTechnol　2018~迄今
• Scientific Reports　2016~迄今
• Journal of Food and Drug Analysis　2016~迄今
• PLOS one　2013~迄今
• Genes　2016
• Indoor Air　2016
• General Physiology and Biophysics　2014

校內外服務

• 109年科技部生科司食品安全學門專題計畫初審委員　2020/02
• 化學局新化學物質標準登錄審查技術顧問　2019~
• 國立成功大學食品安全衛生暨碩士班生化考題命題　2017~
• 碩士班甄試/考試面試委員　2017~
• 成大環境醫學研究所碩士論文口試委員　2018~
• 高雄師範大學生物科技研究所碩士論文口試委員　2018
• 國立中興大學生物科技研究所碩士論文口試委員　2019~
• 國立成功大學食品安全衛生暨風險管理研究所碩士論文口試委員　2019~